Pisa综合征是否会影响帕金森病患者的上肢功能？一项观察性横断面研究。

Does Pisa syndrome affect upper limb function in patients with Parkinson's disease? An observational cross-sectional study.

作者信息

Alwardat Mohammad, Di Lazzaro Giulia, Schirinzi Tommaso, Sinibaldi Salime Paola, Mercuri Nicola Biagio, Pisani Antonio

机构信息

Department of Systems Medicine, University of Roma "Tor Vergata", Rome, Italy.

Neuroscience PhD School, University of Rome "Tor Vergata", Rome, Italy.

出版信息

NeuroRehabilitation. 2018;42(2):143-148. doi: 10.3233/NRE-172274.

DOI:10.3233/NRE-172274

PMID:29562562

Abstract

BACKGROUND

Trunk alignment is thought to contribute to upper limb (UL) function. However, this common assumption is not clear in patients with Parkinson's Disease (PD) suffering from Pisa syndrome (PS). PS is a postural abnormality, characterized by revisable lateral trunk flexion more than 10 degrees.

OBJECTIVE

To investigate the UL functioning and activities of daily living in PD patients with PS.

METHODS

Forty-five participants distributed equally in three groups PD patients with PS, PD patients without PS and age/sex matched healthy controls (HC). The function and disability of UL was assessed by Arm Shoulder and Hand (DASH) questionnaire for all groups. PD groups then completed clinical assessments by the Unified Parkinson's Disease Rating Scale (UPDRS) part II-III, Modified Hoenh & Yahr (mH&Y) staging and the Levodopa Equivalent Daily Dose (LEDD).

RESULTS

Three groups showed significant differences in DASH questionnaire (p < 0.001) with higher scores for PS group, intermediate for PD group and lower for HC group. PS group also showed higher score in UPDRS-II and mH&Y (p = 0.019), while no differences emerged between PD and PS in UPDRS-III score and LEDD.

CONCLUSION

Our results demonstrated that PS is associated with major impairment of both UL functioning and activities of daily living in PD patients.

摘要

背景

躯干对线被认为有助于上肢（UL）功能。然而，在患有 Pisa 综合征（PS）的帕金森病（PD）患者中，这一普遍假设并不明确。PS 是一种姿势异常，其特征为可纠正的侧躯干屈曲超过 10 度。

目的

研究患有 PS 的 PD 患者的上肢功能和日常生活活动情况。

方法

45 名参与者平均分为三组：患有 PS 的 PD 患者、不患有 PS 的 PD 患者以及年龄/性别匹配的健康对照（HC）。所有组均通过手臂、肩部和手部（DASH）问卷评估上肢的功能和残疾情况。然后，PD 组通过统一帕金森病评定量表（UPDRS）第二至三部分、改良 Hoehn & Yahr（mH&Y）分期以及左旋多巴等效日剂量（LEDD）完成临床评估。