Cho Sung-Woo, Han Doo Hee, Kim Jeong-Whun, Kim Dong-Young, Rhee Chae-Seo
Department of Otorhinolaryngology-Head & Neck Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea.
Department of Otorhinolaryngology-Head & Neck Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.
Immunotherapy. 2018 Jun;10(7):567-578. doi: 10.2217/imt-2018-0013. Epub 2018 Mar 22.
Allergen immunotherapy has been shown to be effective in treatment of allergic rhinitis (AR). Sublingual immunotherapy (SLIT) is generally recommended for treating seasonal AR in adults and children; however, questions remain in regard to AR treatment in relation to house dust mite (HDM). Due to heterogeneous formulations, different outcome reporting systems, and the lack of a standardized dose, HDM SLITs have not been standardized in published studies. Nevertheless, studies continuously report positive effects of HDM SLIT in AR, and HDM SLIT remains a treatment option for patients with HDM-induced allergic asthma that frequently co-exists with AR. Therefore, it is likely that HDM SLIT usage will increase. This review will focus on HDM SLIT in AR exclusively.
变应原免疫疗法已被证明对过敏性鼻炎（AR）的治疗有效。舌下免疫疗法（SLIT）通常被推荐用于治疗成人和儿童的季节性AR；然而，关于屋尘螨（HDM）相关的AR治疗仍存在问题。由于制剂的异质性、不同的结果报告系统以及缺乏标准化剂量，已发表的研究中HDM SLIT尚未标准化。尽管如此，研究不断报告HDM SLIT对AR有积极作用，并且HDM SLIT仍然是与AR经常共存的HDM诱发的过敏性哮喘患者的一种治疗选择。因此，HDM SLIT的使用可能会增加。本综述将专门关注AR中的HDM SLIT。
