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血管生成在硬脑膜动静脉瘘中的作用:迄今为止的情况。

The role of angiogenesis in dural arteriovenous fistulae: the story so far.

作者信息

Bhogal Pervinder, Yeo Leonard L, Henkes Hans, Krings Timo, Söderman Michael

机构信息

1 Neuroradiological Clinic, Klinikum Stuttgart, Stuttgart, Germany.

2 Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.

出版信息

Interv Neuroradiol. 2018 Aug;24(4):450-454. doi: 10.1177/1591019918764090. Epub 2018 Mar 21.

Abstract

Intracranial dural arteriovenous fistulae are a commonly encountered pathology that can present with a variety of different clinical symptoms. Although there is a significant body of work relating to the natural history and treatment of dural arteriovenous fistulae the exact underlying pathogenesis remains elusive. Various different pathogenetic models have been put forward but there is now a growing body of evidence implicating angiogenesis and the involvement of angiogenetic factors. In this review we attempt to show how the various animal and human studies performed over the past two decades have contributed to the proposed hypothesis on the development of dural arteriovenous fistulae.

摘要

颅内硬脑膜动静脉瘘是一种常见的病理情况,可表现出多种不同的临床症状。尽管有大量关于硬脑膜动静脉瘘自然病史和治疗的研究工作,但确切的潜在发病机制仍不清楚。已经提出了各种不同的发病机制模型,但现在越来越多的证据表明血管生成和血管生成因子的参与。在这篇综述中,我们试图展示过去二十年来进行的各种动物和人体研究如何促成了关于硬脑膜动静脉瘘发展的假说。

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