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Platelet Signaling Pathways and New Inhibitors.

作者信息

Grover Steven P, Bergmeier Wolfgang, Mackman Nigel

机构信息

From the Thrombosis and Hemostasis Program, Division of Hematology and Oncology, Department of Medicine (S.P.G., N.M.) and McAllister Heart Institute and Department of Biochemistry and Biophysics (W.B.), University of North Carolina at Chapel Hill.

出版信息

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):e28-e35. doi: 10.1161/ATVBAHA.118.310224.

DOI:10.1161/ATVBAHA.118.310224

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5989728/

Abstract

摘要

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[1]

PAR4 (Protease-Activated Receptor 4): PARticularly Important 4 Antiplatelet Therapy.

Arterioscler Thromb Vasc Biol. 2018-2

[2]

12-HETrE inhibits platelet reactivity and thrombosis in part through the prostacyclin receptor.

Blood Adv. 2017-6-23

[3]

Filamin A Modulates Store-Operated Ca Entry by Regulating STIM1 (Stromal Interaction Molecule 1)-Orai1 Association in Human Platelets.

Arterioscler Thromb Vasc Biol. 2017-12-28

[4]

PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation.

Arterioscler Thromb Vasc Biol. 2017-12-21

[5]

TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.

Arterioscler Thromb Vasc Biol. 2017-11-16

[6]

A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

Blood. 2017-11-2

[7]

Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase.

Arterioscler Thromb Vasc Biol. 2017-11

[8]

Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy.

Trends Pharmacol Sci. 2017-8-29

[9]

First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.

Arterioscler Thromb Vasc Biol. 2017-10

[10]

Inner Mitochondrial Membrane Disruption Links Apoptotic and Agonist-Initiated Phosphatidylserine Externalization in Platelets.

Arterioscler Thromb Vasc Biol. 2017-8

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