家庭夜间指脉搏血氧仪同步评估的动态血压与氧减饱和指数的关系。
Ambulatory blood pressure in relation to oxygen desaturation index as simultaneously assessed by nighttime finger pulse oximetry at home.
机构信息
Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Philips Research China, Shanghai, China.
出版信息
J Clin Hypertens (Greenwich). 2018 Apr;20(4):648-655. doi: 10.1111/jch.13254. Epub 2018 Mar 22.
We investigated the relationship between ambulatory blood pressure (BP) and oxygen desaturation index (ODI), while accounting for pulse rate and age. ODI was assessed by overnight finger pulse oximetry in 2342 participants on the day of ambulatory BP monitoring, and calculated as the number of desaturation episodes per sleeping hour. Both BP and pulse rate increased significantly (P ≤ .006) from normal (< 5 events/h) to mildly (5-14), moderately (15-30), and severely (≥ 30 events/h) elevated ODI. The association for BP was substantially attenuated by accounting for pulse rate (partial r² from .003-.012 to .002-.006). In adjusted analysis, the associations of 24-hour diastolic BP and 24-hour pulse rate with ODI were dependent on age (P ≤ .0001) and only significant in younger subjects (< 60 years, P ≤ .0001). In conclusion, the association between ambulatory BP and ODI was partially mediated by pulse rate, a measure of sympathetic activity, and was more prominent in younger subjects.
我们研究了动态血压（BP）与氧减饱和度指数（ODI）之间的关系，同时考虑了脉搏率和年龄因素。在 2342 名接受动态血压监测的参与者中，通过夜间手指脉搏血氧饱和度监测评估了 ODI，并计算为每小时睡眠中发生的脱氧饱和度事件数。BP 和脉搏率均显著增加（P ≤.006），从正常（< 5 次/小时）到轻度（5-14 次）、中度（15-30 次）和重度（≥ 30 次/小时）升高 ODI。通过考虑脉搏率，BP 的相关性明显减弱（部分 r² 从.003-.012 降至.002-.006）。在调整分析中，24 小时舒张压和 24 小时脉搏率与 ODI 的关联取决于年龄（P ≤.0001），仅在年轻受试者中具有显著性（< 60 岁，P ≤.0001）。总之，动态血压与 ODI 之间的关联部分由反映交感神经活动的脉搏率介导，在年轻受试者中更为明显。
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