纤维肌痛综合征与小纤维、早期或轻度感觉性多发性神经病。
Fibromyalgia syndrome and small fiber, early or mild sensory polyneuropathy.
机构信息
Dartmouth-Hitchcock Medical Center Department of Neurology, One Medical Center Drive, Lebanon, New Hampshire, 03766, USA.
Ohio State University Medical Center Department of Neurology, Columbus, Ohio, USA.
出版信息
Muscle Nerve. 2018 Nov;58(5):625-630. doi: 10.1002/mus.26131. Epub 2018 Apr 26.
INTRODUCTION
Pain mechanisms in fibromyalgia syndrome (FMS) are not clearly understood. Growing evidence appears to suggest a role for small fiber polyneuropathy (SFPN) in some FMS patients, as measured by epidermal nerve fiber density (ENFD). We aimed to better characterize and distinguish the subset of patients with both fibromyalgia and small fiber, early or mild sensory polyneuropathy (FM-SFSPN).
METHODS
155 FMS patients with neuropathic symptoms completed a Short Form McGill Questionnaire and visual analog scale in addition to having skin biopsies, nerve conduction studies (NCS), and serologic testing.
RESULTS
Sural and medial plantar (MP) response amplitudes correlated with ENFD, with markers of metabolic syndrome being more prevalent in this subset of patients. Pain intensity and quality did not distinguish patients.
DISCUSSION
The FM-SFSPN subset of patients may be identified through sural and MP sensory NCS and/or skin biopsy but cannot be identified by pain features and intensity. Muscle Nerve 58: 625-630, 2018.
简介
纤维肌痛综合征（FMS）的疼痛机制尚不清楚。越来越多的证据表明，小纤维多神经病（SFPN）在某些 FMS 患者中起作用，这可以通过表皮神经纤维密度（ENFD）来衡量。我们旨在更好地描述和区分同时患有纤维肌痛和小纤维、早期或轻度感觉性多发性神经病（FM-SFSPN）的患者亚组。
方法
155 名有神经病理性症状的 FMS 患者完成了简短形式麦吉尔问卷和视觉模拟评分，此外还进行了皮肤活检、神经传导研究（NCS）和血清学检测。
结果
腓肠和内侧足底（MP）反应幅度与 ENFD 相关，代谢综合征的标志物在这组患者中更为普遍。疼痛强度和质量无法区分患者。
讨论
FM-SFSPN 患者亚组可通过腓肠和 MP 感觉性 NCS 和/或皮肤活检来识别，但不能通过疼痛特征和强度来识别。肌肉神经 58:625-630,2018.
Zotero 插件