婴儿痉挛症的详细磁共振成像（MRI）分析
Detailed Magnetic Resonance Imaging (MRI) Analysis in Infantile Spasms.
作者信息
Harini Chellamani, Sharda Sonal, Bergin Ann Marie, Poduri Annapurna, Yuskaitis Christopher J, Peters Jurriaan M, Rakesh Kshitiz, Kapur Kush, Pearl Phillip L, Prabhu Sanjay P
机构信息
1 Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
2 Johns Hopkins University, Baltimore, MD, USA.
出版信息
J Child Neurol. 2018 May;33(6):405-412. doi: 10.1177/0883073818760424. Epub 2018 Mar 26.
PURPOSE
To evaluate initial magnetic resonance imaging (MRI) abnormalities in infantile spasms, correlate them to clinical characteristics, and describe repeat imaging findings.
METHODS
A retrospective review of infantile spasm patients was conducted, classifying abnormal MRI into developmental, acquired, and nonspecific subgroups.
RESULTS
MRIs were abnormal in 52 of 71 infantile spasm patients (23 developmental, 23 acquired, and 6 nonspecific) with no correlation to the clinical infantile spasm characteristics. Both developmental and acquired subgroups exhibited cortical gray and/or white matter abnormalities. Additional abnormalities of deep gray structures, brain stem, callosum, and volume loss occurred in the structural acquired subgroup. Repeat MRI showed better definition of the extent of existing malformations.
CONCLUSION
In structural infantile spasms, developmental/acquired subgroups showed differences in pattern of MRI abnormalities but did not correlate with clinical characteristics.
目的
评估婴儿痉挛症的初始磁共振成像（MRI）异常情况，将其与临床特征相关联，并描述重复成像结果。
方法
对婴儿痉挛症患者进行回顾性研究，将异常MRI分为发育性、获得性和非特异性亚组。
结果
71例婴儿痉挛症患者中52例MRI异常（23例发育性、23例获得性和6例非特异性），与临床婴儿痉挛症特征无相关性。发育性和获得性亚组均表现为皮质灰质和/或白质异常。结构性获得性亚组还出现深部灰质结构、脑干、胼胝体的其他异常及体积减小。重复MRI显示现有畸形范围的清晰度更高。
结论
在结构性婴儿痉挛症中，发育性/获得性亚组在MRI异常模式上存在差异，但与临床特征无关。
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