Nyman R, Rehn S, Glimelius B, Hagberg H, Hemmingsson A, Lindgren P G, Magnusson A
Department of Diagnostic Radiology, Akademiska Sjukhuset, University of Uppsala, Sweden.
Acta Radiol. 1987 May-Jun;28(3):253-62.
Magnetic resonance imaging (MRI) was compared with chest radiography, computed tomography (CT) and ultrasonography (US) for demonstration of spleen and liver engagement and enlarged lymph nodes in patients with malignant lymphoma. The investigation comprised 24 patients with Hodgkin's disease (HD) and 39 with non-Hodgkin lymphoma (NHL). MRI demonstrated enlarged lymph nodes, distinctly separated from vessels, fat, muscle, liver and occasionally also pancreas without any contrast medium. The distinction between lymph nodes and spleen was, however, poor in the images. In the mediastinum, MRI was superior to chest radiography and had an accuracy similar to that of CT. In the abdomen and the pelvis MRI had slight advantages over CT in detection of enlarged lymph nodes. Compared with US the MRI results were similar in the abdomen and somewhat better in the pelvis. MRI and US were better than CT in revealing HD infiltrates in the spleen. Infiltration of NHL in the spleen was slightly better disclosed at US than at CT and MRI; most of the NHL infiltration, confirmed at histopathology, could, however, not be revealed with any of the modalities, except when the size of the spleen was considered. Regions in the spleen, displayed with low image intensity in the T2 weighted image, were most likely due to increased amount of fibrotic tissue in the lymphomatous lesions. Good demonstration of lymph nodes and lymphomatous lesions in the spleen with MRI required two sequences; one with short TR and TE (T1 weighted image) and one with long TR and TE (T2 weighted image).
对24例霍奇金病（HD）患者和39例非霍奇金淋巴瘤（NHL）患者进行了磁共振成像（MRI）检查，并与胸部X线摄影、计算机断层扫描（CT）和超声检查（US）进行比较，以观察脾脏和肝脏受累情况以及肿大的淋巴结。MRI可显示肿大的淋巴结，其与血管、脂肪、肌肉、肝脏，偶尔也与胰腺明显分开，无需使用任何造影剂。然而，在图像中淋巴结与脾脏的区分较差。在纵隔，MRI优于胸部X线摄影，其准确性与CT相似。在腹部和盆腔，MRI在检测肿大淋巴结方面比CT略有优势。与US相比，MRI在腹部的结果相似，在盆腔则稍好。在显示脾脏中的HD浸润方面，MRI和US优于CT。NHL在脾脏中的浸润在US检查时比CT和MRI稍易显示；然而，除考虑脾脏大小外，组织病理学证实的大多数NHL浸润在任何一种检查方式下均无法显示。在T2加权图像中显示为低图像强度的脾脏区域，很可能是由于淋巴瘤病变中纤维组织增多所致。要通过MRI良好地显示脾脏中的淋巴结和淋巴瘤病变，需要两个序列；一个是短TR和TE（T1加权图像），另一个是长TR和TE（T2加权图像）。
