Kothe R
Klinik für Spinale Chirurgie, Schön Klinik Eilbek, Dehnhaide 120, 22081, Hamburg, Deutschland.
Orthopade. 2018 Jun;47(6):489-495. doi: 10.1007/s00132-018-3563-2.
The involvement of the cervical spine in rheumatoid arthritis (RA) continues to be of clinical importance even in this age of biologics. Pathophysiological changes begin with an isolated atlantoaxial subluxation and may progress to a complex craniocervical and subaxial instability. The onset of cervical myelopathy can occur at any time and leads to a deterioration of the prognosis for the patient.
Treatment of the rheumatoid cervical spine should be aimed at improvement of the symptoms and prevention of further progress of the disease. In the case of instability, this is only possible by surgical treatment. The increasing usage of biological agents has led to a change in the clinical picture of the cervical involvement in RA patients. There are fewer patients presenting with isolated atlantoaxial instability. In contrast, the number of patients with complex craniocervical and/or subaxial instabilities is increasing. Complex cervical instabilities may require a longer fusion from the occiput to the upper thoracic spine. Modern operative techniques make this complex surgery also possible in severely disabled patients with a high comorbidity.
即使在生物制剂时代,颈椎受累于类风湿性关节炎(RA)仍具有临床重要性。病理生理变化始于孤立的寰枢椎半脱位,并可能进展为复杂的颅颈和下颈椎不稳定。颈椎脊髓病可在任何时候发病,并导致患者预后恶化。
类风湿性颈椎的治疗应旨在改善症状并防止疾病进一步发展。对于不稳定情况,只有通过手术治疗才有可能。生物制剂使用的增加导致了RA患者颈椎受累临床表现的改变。出现孤立寰枢椎不稳定的患者减少。相反,具有复杂颅颈和/或下颈椎不稳定的患者数量正在增加。复杂的颈椎不稳定可能需要从枕骨到上胸椎进行更长节段的融合。现代手术技术使这种复杂手术在合并症高的严重残疾患者中也成为可能。