Krishan K, Kanchan T, Singh B, Baryah N, Puri S
Associate Professor and Chair, Department of Anthropology, Panjab University, Sector-14, Chandigarh, India.
Associate Professor - Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, Jodhpur, India.
Clin Ter. 2018 Mar-Apr;169(2):e58-e59. doi: 10.7417/T.2018.2053.
This communication is regarding the recent editing of the genome of the human embryo with CRISPR/Cas9 which generated a debate amongst the biological scientists around the world. Editing human germline genes may act as godsend in some serious genetic and other disorders as the genes related to these disorders can be replaced effectively. The scientists are in dilemma whether the human germline gene modification is a boon or bane for the human society. Though editing human germline genes may be an answer to many serious genetic disorders however; it may have unpredictable effects on future generations. The ethical issues regarding the germline editing need further discussion which may have implications on human race and on-going human evolution. Thus, the researchers need to be doubly cautious and some stringent regulations should be framed regarding the various aspects of germ line gene modifications and any potential conflict with nature for future outcome.
本通讯是关于最近利用CRISPR/Cas9对人类胚胎基因组进行编辑的事件,这在全球生物科学家之间引发了一场辩论。编辑人类生殖系基因在某些严重的遗传及其他疾病中可能是天赐之物,因为与这些疾病相关的基因能够被有效替换。科学家们陷入两难境地,即人类生殖系基因改造对人类社会是福是祸。虽然编辑人类生殖系基因可能是许多严重遗传疾病的解决方案,然而,它可能对后代产生不可预测的影响。关于生殖系编辑的伦理问题需要进一步讨论,这可能会对人类种族和正在进行的人类进化产生影响。因此,研究人员需要加倍谨慎,并且应该针对生殖系基因改造的各个方面以及未来结果与自然的任何潜在冲突制定一些严格的规定。