鱼类中的雌性生殖细胞具有内在的雌性化效应。
Germ cells in the teleost fish medaka have an inherent feminizing effect.
机构信息
Division of Biological Science, Nagoya University, Nagoya, Aichi, Japan.
Genetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka, Japan.
出版信息
PLoS Genet. 2018 Mar 29;14(3):e1007259. doi: 10.1371/journal.pgen.1007259. eCollection 2018 Mar.
Germ cells are the only cells that can transfer genetic materials to the next generation via the sperm or egg. However, recent analyses in teleosts revealed another essential role of germ cells: feminizing the gonads. In our study, medaka mutants in which gametogenesis was blocked at specific stages provides the novel view that the feminizing effect of germ cells occurs in parallel with other reproductive elements, such as meiosis, the sexual fate decision of germ cells, and gametogenesis. Germ cells in medaka may have a potential to feminize gonads at the moment they have developed.
生殖细胞是唯一能够通过精子或卵子将遗传物质传递给下一代的细胞。然而，最近对硬骨鱼类的分析揭示了生殖细胞的另一个重要作用：使性腺雌性化。在我们的研究中，在特定阶段阻断配子发生的斑马鱼突变体提供了一个新的观点，即生殖细胞的雌性化作用与其他生殖元素平行发生，如减数分裂、生殖细胞的性命运决定和配子发生。斑马鱼的生殖细胞可能在发育成熟的那一刻就有使性腺雌性化的潜力。
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