Nanashima Atsushi, Imamura Naoya, Sumida Yorihisa, Hiyoshi Masahide, Hamada Takeomi, Nagayasu Takeshi
Division of Hepato-Biliary-Pancreas Surgery, Department of Surgery, University of Miyazaki Faculty of Medicine, Kiyotake, Japan
Division of Hepato-Biliary-Pancreas Surgery, Department of Surgery, University of Miyazaki Faculty of Medicine, Kiyotake, Japan.
Anticancer Res. 2018 Apr;38(4):2343-2352. doi: 10.21873/anticanres.12481.
BACKGROUND/AIM: Intraductal papillary neoplasm of the bile duct (IPNB) is defined as a non-invasive malignancy and disparity of its histological diagnosis with related diseases remains.
Twenty-six cases of IPNB and 12 of papillary adenocarcinomas (PAC) at two Institutes were investigated.
The prevalence of biliary dilatation and mucin secretion in the group with IPNB was significantly higher compared to the group with PAC (p<0.01). IPNB was predominantly located in the proximal bile duct compared to the location of PAC (p<0.01). Mis-matching of a second histological diagnosis was observed in 27% of IPNB and 25% of PAC, respectively. The prevalence of tumor relapse was significantly higher in PAC than in IPNB (p<0.05), and the overall survival was significantly better in IPNB than in PAC (p<0.01).
Although IPNB is currently defined under histological criteria, morphologies were various and disparity in histological diagnosis for IPNB remains problematic when the clinical strategy is contemplated.
背景/目的：胆管内乳头状肿瘤（IPNB）被定义为一种非侵袭性恶性肿瘤，其组织学诊断与相关疾病之间仍存在差异。
对两家机构的26例IPNB病例和12例乳头状腺癌（PAC）病例进行了研究。
与PAC组相比，IPNB组的胆管扩张和黏液分泌发生率显著更高（p<0.01）。与PAC的位置相比，IPNB主要位于近端胆管（p<0.01）。分别在27%的IPNB和25%的PAC中观察到二次组织学诊断不匹配。PAC的肿瘤复发率显著高于IPNB（p<0.05），IPNB的总生存率显著优于PAC（p<0.01）。
尽管目前IPNB是根据组织学标准定义的，但其形态多样，在考虑临床策略时，IPNB的组织学诊断差异仍然存在问题。
