Neuromusculoskeletal Lab (NMSK), Secteur des Sciences de la Santé, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.
Service d'hématologie, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Haemophilia. 2018 May;24(3):e103-e112. doi: 10.1111/hae.13467. Epub 2018 Mar 30.
To measure passive musculoarticular ankle stiffness (PMAAS) and its intra- and interday reliability in adult control subjects without ankle disorders. We also sought to quantify PMAAS in children, adolescents and young adults with haemophilia (CAAwH) taking into account the accurate tibiotalar and subtalar joints structural status obtained by magnetic resonance imaging (MRI).
We included 23 CAAwH and 23 typically developing boys (TDB) matched by age, weight and height, along with 25 healthy volunteers for reliability assessment. All CAAwH underwent bilateral ankle MRI, with anatomical status assessed using the International Prophylaxis Study Group MRI scale. All CAAwH underwent PMAAS testing for both sides randomly vs the dominant side (DS) in TDBs. For assessing viscous stiffness (VS) and elastic stiffness (ES), eight different oscillation frequencies were randomly repeated three times for each subject.
Good-to-excellent intra- and interday reliability was observed for ES and VS variables. No relevant differences were observed between the ankle viscoelastic properties in CAAwH without joint damage and matched TDBs, whereas the study revealed significantly increased ES in the affected ankles of CAAwH with severe unilateral joint involvement compared to the non-affected joint.
This study confirmed increased ES in the severely affected ankles of CAAwH compared to non-affected sides. No differences in the ankle viscoelastic properties of CAAwH with or without joint damage were observed, however, compared to matched TDB.
测量无踝关节疾病的成人对照组的被动关节踝刚度（PMAAS）及其日内和日间可靠性。我们还试图通过磁共振成像（MRI）量化儿童、青少年和年轻血友病患者（CAAwH）的 PMAAS，并考虑到准确的距下关节和跗骨关节结构状况。
我们纳入了 23 名 CAAwH 和 23 名年龄、体重和身高匹配的典型发育男孩（TDB），以及 25 名健康志愿者进行可靠性评估。所有 CAAwH 均接受双侧踝关节 MRI 检查，使用国际预防研究组 MRI 量表评估解剖结构状况。所有 CAAwH 均随机接受双侧 PMAAS 测试，而 TDB 则随机接受对侧（DS）测试。为了评估粘性刚度（VS）和弹性刚度（ES），对于每个个体，我们随机重复了 8 个不同的振动频率三次。
ES 和 VS 变量的日内和日间可靠性均较好。未观察到无关节损伤的 CAAwH 和匹配的 TDB 之间踝关节粘弹性差异，而研究显示，严重单侧关节受累的 CAAwH 受累踝关节的 ES 显著增加，与未受累关节相比。
与未受累侧相比，本研究证实了 CAAwH 严重受累踝关节的 ES 增加。然而，与匹配的 TDB 相比，无论 CAAwH 是否有关节损伤，踝关节粘弹性特性均无差异。
