Cardiac telocytes. From basic science to cardiac diseases. II. Acute myocardial infarction.

INTRODUCTION

The purpose of this study was to evaluate the scientific evidence regarding a potential role of telocytes in myocardial infarction.

MATERIALS AND METHODS

To this purpose, we performed a systematic review of relevant scientific literature, indexed in PubMed, Web of Science, and Scopus.

RESULTS AND DISCUSSIONS

We found six articles containing relevant studies aimed at liking myocardial infarction and telocytes. The studies that were analysed in this review failed to show, beyond a reasonable doubt, that telocytes do actually have significant roles in myocardial regeneration after myocardial infarction. The main issues to be addressed in future studies are a correct characterization of telocytes, and a differentiation from other cell types that either have similar morphologies (using electron microscopy) or similar immunophenotypes, with emphasis on endothelial progenitors, which were previously shown to have similar morphology, and functions in cardiac regeneration after myocardial infarction.