非乙酰氨基酚类药物导致的急性肝衰竭。

Nonacetaminophen Drug-Induced Acute Liver Failure.

机构信息

MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20007, USA.

Division of Gastroenterology, MedStar Georgetown University Hospital, 3800 Reservoir Road Northwest, Room M2408, Washington, DC 20007, USA.

出版信息

Clin Liver Dis. 2018 May;22(2):301-324. doi: 10.1016/j.cld.2018.01.006. Epub 2018 Feb 7.

DOI:10.1016/j.cld.2018.01.006

PMID:29605068

Abstract

Acute liver failure of all causes is diagnosed in between 2000 and 2500 patients annually in the United States. Drug-induced acute liver failure is the leading cause of acute liver failure, accounting for more than 50% of cases. Nonacetaminophen drug injury represents 11% of all cases in the latest registry from the US Acute Liver Failure Study Group. Although rare, acute liver failure is clinically dramatic when it occurs, and requires a multidisciplinary approach to management. In contrast with acetaminophen-induced acute liver failure, non-acetaminophen-induced acute liver failure has a more ominous prognosis with a lower liver transplant-free survival.

摘要

在美国，每年有 2000 至 2500 例各种病因导致的急性肝衰竭患者被确诊。药物性急性肝衰竭是急性肝衰竭的主要病因，占比超过 50%。在最近的美国急性肝衰竭研究组登记报告中，非乙酰氨基酚药物损伤占所有病例的 11%。尽管较为罕见，但当急性肝衰竭发生时，其临床表现十分显著，需要多学科的方法进行管理。与乙酰氨基酚所致急性肝衰竭不同，非乙酰氨基酚所致急性肝衰竭的预后更差，肝移植存活率更低。