Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, People's Republic of China; Key Laboratory of Cancer Prevention and Therapy, Tianjin, People's Republic of China; Tianjin's Clinical Research Center for Cancer, People's Republic of China.
Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, People's Republic of China; Key Laboratory of Cancer Prevention and Therapy, Tianjin, People's Republic of China; Tianjin's Clinical Research Center for Cancer, People's Republic of China.
Asian J Surg. 2018 Nov;41(6):530-536. doi: 10.1016/j.asjsur.2018.02.006. Epub 2018 Mar 31.
BACKGROUND/OBJECTIVE: A retrospective review is required to assess the application effect of percutaneous cryoablation on the stage IIIB/IV advanced non-small-cell lung cancer (NSCLC) after the failure of chemoradiotherapy. A total of twenty-two cases with stage IIIB/IV advanced NSCLC after failure of chemoradiotherapy were enrolled.
Computed Tomography (CT) was used for the assessment of tumor response, and Functional Assessment of Cancer Therapy-General (FACT-G) was applied for the evaluation of quality of life. After the treatment of cryoablation, we performed a follow-up analysis.
The primary technique effectiveness of 100% was observed in the one month of follow-up. At three months, local tumor progression was shown in 4 of 31 lesions (13.6%). The one-year survival rate of 81.8% and progression-free rate of 27.8% were obtained. Six patients died 7, 9, 10, 12, 15 and 22 months after treatment, respectively. Decreased scores of total quality of life at one week after cryoablation (P = 0.006), but increased scores at one month after cryoablation (P = 0.024) were observed, compared with pre-cryoablation.
Cryoablation contributes to the effective local tumor therapy for stage IIIB/IV advanced NSCLC after the failure of chemoradiotherapy.
背景/目的：需要进行回顾性研究，以评估经化学放疗失败后的Ⅲ B/Ⅳ期非小细胞肺癌（NSCLC）患者行经皮冷冻消融术的应用效果。共纳入 22 例经化学放疗失败后的Ⅲ B/Ⅳ期 NSCLC 患者。
采用计算机断层扫描（CT）评估肿瘤反应，采用癌症治疗功能评估-一般量表（FACT-G）评估生活质量。在冷冻消融治疗后进行随访分析。
在 1 个月的随访中，主要技术有效率为 100%。在 3 个月时，31 个病灶中有 4 个（13.6%）出现局部肿瘤进展。1 年生存率为 81.8%，无进展生存率为 27.8%。6 例患者分别在治疗后 7、9、10、12、15 和 22 个月死亡。与冷冻消融前相比，冷冻消融后 1 周的总生活质量评分降低（P=0.006），而冷冻消融后 1 个月的评分升高（P=0.024）。
冷冻消融术可有效治疗经化学放疗失败后的Ⅲ B/Ⅳ期 NSCLC。
