Shippenberg T S, Herz A
Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, Planegg-Martinsried, F.R.G.
Brain Res. 1987 Dec 8;436(1):169-72. doi: 10.1016/0006-8993(87)91571-x.
The role of D1 dopamine receptors in mediating the motivational properties of opioid agonists was investigated by use of place preference conditioning. Administration of the D1 receptor antagonist SCH 23390 (0.001-0.5 mg/kg) or the kappa-opioid receptor agonist U-69593 (0.16 mg/kg) produced conditioned place aversions. In contrast, the mu-opioid agonist, morphine (3.0 mg/kg) was appetitively reinforcing. Chronic infusion of SCH 23390 (1.0 mg/kg/day) during conditioning abolished the effects of both opioid agonists. These data demonstrate the specific involvement of D1 receptors in the motivational properties of mu- and kappa-opioid agonists and suggest that dopaminergic systems are crucial for the expression of both reinforcing and aversive motivational states.
通过位置偏爱条件反射实验研究了D1多巴胺受体在介导阿片类激动剂的动机特性中的作用。给予D1受体拮抗剂SCH 23390（0.001 - 0.5毫克/千克）或κ-阿片受体激动剂U - 69593（0.16毫克/千克）会产生条件性位置厌恶。相比之下，μ-阿片激动剂吗啡（3.0毫克/千克）具有奖赏性强化作用。在条件反射过程中慢性输注SCH 23390（1.0毫克/千克/天）消除了两种阿片类激动剂的作用。这些数据表明D1受体特异性参与了μ-和κ-阿片激动剂的动机特性，并提示多巴胺能系统对于奖赏性和厌恶性动机状态的表达至关重要。
