Gijsbertse Kaj, Sprengers André, Naghibi Beidokhti Hamid, Nillesen Maartje, de Korte Chris, Verdonschot Nico
Orthopaedic Research Laboratory, Department of Orthopedics, Radboud University Medical Center, Nijmegen, The Netherlands.
Orthopaedic Research Laboratory, Department of Orthopedics, Radboud University Medical Center, Nijmegen, The Netherlands; Laboratory of Biomechanical Engineering, University of Twente, Enschede, The Netherlands.
J Biomech. 2018 May 17;73:233-237. doi: 10.1016/j.jbiomech.2018.03.035. Epub 2018 Mar 29.
Recent first attempts of in situ ultrasound strain imaging in collateral ligaments encountered a number of challenges and illustrated a clear need for additional studies and more thorough validation of the available strain imaging methods. Therefore, in this study we experimentally validated ultrasound strain measurements of ex vivo human lateral collateral ligaments in an axial loading condition. Moreover, the use of high frequency ultrasound (>20 MHz) for strain measurement was explored and its performance compared to conventional ultrasound. The ligaments were stretched up to 5% strain and ultrasound measurements were compared to surface strain measurements from optical digital image correlation (DIC) techniques. The results show good correlations between ultrasound based and DIC based strain measures with R values of 0.71 and 0.93 for high frequency and conventional ultrasound, subsequently. The performance of conventional ultrasound was significantly higher compared to high frequency ultrasound strain imaging, as the high frequency based method seemed more prone to errors. This study demonstrates that ultrasound strain imaging is feasible in ex vivo lateral collateral ligaments, which are relatively small structures. Additional studies should be designed for a more informed assessment of optimal in vivo strain measurements in collateral knee ligaments.
近期在侧副韧带中进行原位超声应变成像的首次尝试遇到了一些挑战，这表明显然需要进行更多研究，并对现有的应变成像方法进行更全面的验证。因此，在本研究中，我们通过实验验证了在轴向加载条件下离体人外侧副韧带的超声应变测量。此外，还探索了使用高频超声（>20MHz）进行应变测量，并将其性能与传统超声进行了比较。将韧带拉伸至5%应变，并将超声测量结果与光学数字图像相关（DIC）技术的表面应变测量结果进行比较。结果表明，基于超声和基于DIC的应变测量之间具有良好的相关性，高频超声和传统超声的R值分别为0.71和0.93。与高频超声应变成像相比，传统超声的性能显著更高，因为基于高频的方法似乎更容易出错。本研究表明，超声应变成像在相对较小的离体外侧副韧带中是可行的。应该设计更多的研究，以便更全面地评估膝侧副韧带最佳体内应变测量方法。
