Pourasl Ali H, Ahmadi Mohammad Taghi, Rahmani Meisam, Ismail Razali
J Nanosci Nanotechnol. 2017 Jan;17(1):601-05. doi: 10.1166/jnn.2017.12537.
As a new nanomaterial, graphene demonstrates great potential as an electrode for biomedical applications in sensing molecules and cells. Thus, development of biosensors based on graphene is gaining much interest due to its exceptional properties such as, large surface-to-volume ratio, high conductivity and high flexibility. In this work a liquid gated graphene field effect transistor based biosensor model is analytically developed for electrical detection of Escherichia Coli O157:H7 bacteria. The effect of graphene functionalization on the graphene conductance in the presence of E. coli is investigated. E. coli absorption effects on the graphene surface in the form of conductance variation are considered. Therefore the graphene conductance as a function of E. coli concentration which controls the current–voltage characteristics of biosensors is presented. According to the simulated results, the proposed sensor model can be applied as a powerful tool to predict the biosensor performance.
作为一种新型纳米材料，石墨烯作为用于生物医学应用中传感分子和细胞的电极展现出巨大潜力。因此，基于石墨烯的生物传感器的开发因其诸如大的表面体积比、高导电性和高柔韧性等优异特性而备受关注。在这项工作中，为了对大肠杆菌O157:H7细菌进行电学检测，解析地建立了一种基于液体栅极石墨烯场效应晶体管的生物传感器模型。研究了石墨烯功能化对存在大肠杆菌时石墨烯电导率的影响。考虑了大肠杆菌以电导率变化形式对石墨烯表面的吸附作用。因此，给出了作为控制生物传感器电流 - 电压特性的大肠杆菌浓度函数的石墨烯电导率。根据模拟结果，所提出的传感器模型可作为预测生物传感器性能的有力工具。
