颅咽管瘤的管理——超越手术和内分泌学的视角
Management of Craniopharyngioma - Perspectives beyond Surgery and Endocrinology.
作者信息
Crowley Rachel K, Thompson Christopher J
机构信息
Consultant Endocrinologist, St Vincent's University Hospital, Elm Park, Dublin, Ireland.
University College Dublin, Dublin, Ireland.
出版信息
Eur Endocrinol. 2015 Aug;11(2):96-97. doi: 10.17925/EE.2015.11.02.96. Epub 2015 Aug 19.
Abstract
The excess mortality in craniopharyngiomas is attributable to their size, site and the traditional surgical approach; aggressive resection predisposes to hypothalamic complications such as obesity, somnolence, thirst disorders and neurocognitive dysfunction. Recently, treatment has been modified to partial resection and radiotherapy. The role of the endocrinologist has expanded from identification and replacement of hormone deficits to include management of hypothalamic disease. Future treatment of craniopharyngioma with neo-adjuvant chemotherapy to minimise surgical resection may improve the outcomes for these patients.
摘要
颅咽管瘤的额外死亡率归因于其大小、位置及传统手术方式；积极切除易引发下丘脑并发症，如肥胖、嗜睡、口渴障碍及神经认知功能障碍。近来，治疗已改为部分切除及放疗。内分泌科医生的作用已从识别和补充激素缺乏扩展至包括下丘脑疾病的管理。未来采用新辅助化疗治疗颅咽管瘤以尽量减少手术切除，可能会改善这些患者的治疗效果。
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