罗库溴铵用于控制一名患有慢性甲基苯丙胺使用障碍的破伤风患者的肌肉痉挛。
Rocuronium for control of muscle spasms in a tetanus patient with chronic methamphetamine use disorder.
作者信息
Enriquez Clare Angeli Guinto, Abejero Joshua Emmanuel Edillon, Ramiro Philip A, Maligaso Carissa Paz Dioquino
机构信息
Department of Neurosciences, University of the Philippines-Philippine General Hospital, Manila, Philippines.
National Poison Management and Control Center (Toxicology), University of the Philippines- Philippine General Hospital, Manila, Philippines.
出版信息
BMJ Case Rep. 2018 Apr 10;2018:bcr-2018-224391. doi: 10.1136/bcr-2018-224391.
This is a case of a 31-year-old Filipino man with chronic methamphetamine use disorder who developed tetanus from a necrotic skin graft over his left calcaneus, which was fractured after a motor vehicular accident. During the course of his illness, the patient's muscle spasms were unusually refractory to benzodiazepine, which is the first-line drug used in the management of muscle spasms. The muscle spasms were successfully controlled on the seventh day of illness with rocuronium at a dose of 10 μg/kg/min and midazolam at 0.30 mg/kg/hour. Both infusions were tapered off until the 23rd day of illness. The patient was discharged on the 30th day of illness, improved and stable.
这是一例31岁的菲律宾男性病例，患有慢性甲基苯丙胺使用障碍，因左跟骨坏死性皮肤移植而感染破伤风，该跟骨在机动车事故后发生骨折。在病程中，患者的肌肉痉挛对苯二氮䓬类药物异常难治，而苯二氮䓬类药物是治疗肌肉痉挛的一线药物。在病程的第七天，使用罗库溴铵，剂量为10μg/kg/分钟，咪达唑仑，剂量为0.30mg/kg/小时，成功控制了肌肉痉挛。两种输注均逐渐减量，直至病程第23天。患者在病程第30天出院，病情改善且稳定。
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