Mahdavinia Mahboobeh, Hui Jessica W, Zitun Mohamed, Lastra Alejandra, Herdegen James J, Codispoti Christopher D, Khan Rafsa J, LoSavio Phillip S, Batra Pete S
From the 1 Allergy/Immunology Section, Department of Immunology and Microbiology, Rush University Medical Center, Chicago, Illinois.
2 Department of Internal Medicine and Pediatrics, Rush University Medical Center, Chicago, Illinois.
Am J Rhinol Allergy. 2018 Mar;32(2):94-97. doi: 10.1177/1945892418762843. Epub 2018 Mar 23.
Patients with chronic rhinosinusitis (CRS) frequently experience sleep disruption and are at a higher than normal risk for obstructive sleep apnea (OSA). The purpose of this study was to determine how CRS affects polysomnography findings and sleep-related breathing in OSA.
A cohort study was performed that included 107 adult patients with CRS and comorbid OSA (CRS+OSA group) and 137 patients with OSA and without CRS as the control group. An electronic medical records database was used to identify eligible subjects. Comorbid conditions and polysomnography data were compared between the two groups by using logistic and linear regression analyses.
A total of 246 patients were included: 107 patients in the CRS+OSA group and 137 patients with OSA and without CRS in the control group. After adjusting for demographic factors, the patients in the CRS+OSA group had a lower body mass index (BMI) and higher age at the time of diagnosis of OSA (p < 0.001). The patients in the CRS+OSA group had higher odds of having asthma and eczema. There was an increase in the periodic limb movement (PLM) index in the CRS+OSA group. Apnea and hypopnea indices were similar in the two groups.
Patients with CRS developed OSA at a lower BMI; patients CRS and OSA had similar sleep-related breathing patterns but higher risks for PLMs compared with patients with OSA and without CRS.
慢性鼻-鼻窦炎（CRS）患者经常出现睡眠中断，患阻塞性睡眠呼吸暂停（OSA）的风险高于正常水平。本研究的目的是确定CRS如何影响OSA患者的多导睡眠图结果和睡眠相关呼吸。
进行了一项队列研究，纳入107例患有CRS合并OSA的成年患者（CRS+OSA组）和137例患有OSA但无CRS的患者作为对照组。使用电子病历数据库识别符合条件的受试者。通过逻辑回归和线性回归分析比较两组的合并症和多导睡眠图数据。
共纳入246例患者：CRS+OSA组107例，对照组137例患有OSA但无CRS。在调整人口统计学因素后，CRS+OSA组患者在诊断OSA时的体重指数（BMI）较低且年龄较大（p<0.001）。CRS+OSA组患者患哮喘和湿疹的几率更高。CRS+OSA组的周期性肢体运动（PLM）指数增加。两组的呼吸暂停和低通气指数相似。
CRS患者在较低的BMI时发生OSA；与无CRS的OSA患者相比，CRS合并OSA患者的睡眠相关呼吸模式相似，但发生PLM的风险更高。
