盐酸丙哌维林对女性混合型尿失禁的治疗效果：盐酸丙哌维林女性尿急和压力性尿失禁研究试验

Therapeutic effect of propiverine hydrochloride on mixed-type urinary incontinence in women: The Female Urgency and Stress Urinary Incontinence Study of Propiverine Hydrochloride trial.

作者信息

Minagawa Tomonori, Gotoh Momokazu, Yokoyama Osamu, Sugaya Kimio, Yamanishi Tomonori, Kawahara Kazuya, Kaga Kanya, Kikuchi Takashi, Nishizawa Osamu

机构信息

Department of Urology, Shinshu University, Matsumoto, Japan.

Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

出版信息

Int J Urol. 2018 May;25(5):486-491. doi: 10.1111/iju.13553. Epub 2018 Apr 12.

DOI:10.1111/iju.13553

PMID:29651806

Abstract

OBJECTIVES

To show the efficacy of propiverine hydrochloride in the management of symptoms of stress urinary incontinence in female patients with mixed-type urinary incontinence.

METHODS

The study was carried out as a multicenter single-arm clinical trial at 64 institutions in Japan. The participants were female patients aged ≥20 years with mixed-type urinary incontinence. The frequency of stress urinary incontinence and urgency urinary incontinence was evaluated at baseline and 4, 8 and 12 weeks after treatment with propiverine hydrochloride. Subjective symptoms were evaluated using the Overactive Bladder Symptom Score and the International Consultation on Incontinence Questionnaire-Short Form. Functional urethral length and maximum urethral closing pressure were also measured at baseline and 12 weeks after treatment at the institutions where the urethral pressure profile was taken.

RESULTS

In total, 49 mixed-type urinary incontinence patients were enrolled in the present study. The number of cases of urgency urinary incontinence was reduced time-dependently, which showed statistically significant differences between baseline and 4, 8 and 12 weeks after treatment. A similar statistically different reduction was also observed for stress urinary incontinence. The mean reduction rates of urgency urinary incontinence and stress urinary incontinence at 12 weeks after treatment were 63.9% and 44.3%, respectively. The total scores of International Consultation on Incontinence Questionnaire-Short Form and Overactive Bladder Symptom Score were gradually reduced, and the differences were statistically significant. Functional urethral length and maximum urethral closing pressure at 12 weeks after treatment did not show any statistical differences compared with those at baseline.

CONCLUSIONS

Propiverine hydrochloride can be an effective therapeutic option for stress urinary incontinence in patients with mixed-type urinary incontinence.

摘要

目的

展示盐酸丙哌维林在治疗混合型尿失禁女性患者压力性尿失禁症状方面的疗效。

方法

本研究作为一项多中心单臂临床试验在日本的64家机构开展。参与者为年龄≥20岁的混合型尿失禁女性患者。在基线期以及使用盐酸丙哌维林治疗后4周、8周和12周时，评估压力性尿失禁和急迫性尿失禁的发生频率。使用膀胱过度活动症症状评分和国际尿失禁咨询问卷简表评估主观症状。在进行尿道压力描记的机构，还在基线期和治疗后12周测量功能性尿道长度和最大尿道闭合压。

结果

本研究共纳入49例混合型尿失禁患者。急迫性尿失禁病例数随时间减少，在基线期与治疗后4周、8周和12周之间显示出统计学显著差异。压力性尿失禁也观察到类似的统计学差异。治疗后12周时，急迫性尿失禁和压力性尿失禁的平均降低率分别为63.9%和44.3%。国际尿失禁咨询问卷简表和膀胱过度活动症症状评分的总分逐渐降低，差异具有统计学意义。治疗后12周时的功能性尿道长度和最大尿道闭合压与基线期相比未显示任何统计学差异。