Section of Neonatology, Department of Paediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
Am J Perinatol. 2018 Oct;35(12):1148-1153. doi: 10.1055/s-0038-1641588. Epub 2018 Apr 13.
To study the impact of cumulative exposure to hypoxemia on the development of retinopathy of prematurity (ROP) in preterm infants less than 29 weeks' gestation.
This is a retrospective analysis of the effect of cumulative exposure to hypoxemia during the first 10 weeks of life in preterm infants <29 weeks' gestation. Cumulative time spent at various levels of oxygen saturation was calculated by converting the daily percentage of time to minutes per day. Cumulative exposure to hypoxemia (cT or oxygen saturation <80%) was calculated weekly and compared between outcomes. The primary outcome was the development of ROP requiring treatment.
Cumulative hypoxemia exposure was significantly associated with ROP requiring treatment. When adjusted for other neonatal morbidities, only gestation was consistently associated with ROP requiring treatment.
Cumulative exposure to hypoxemia in the first few weeks was not associated with ROP or treatment of ROP after adjustment for confounders.
研究早产儿（胎龄<29 周）出生后前 10 周内缺氧暴露累积量对早产儿视网膜病变（ROP）发生发展的影响。
这是一项对胎龄<29 周早产儿出生后前 10 周内缺氧暴露累积量影响的回顾性分析。通过将每日氧饱和度时间百分比转换为每天的分钟数，计算出不同水平的氧饱和度的累积时间。每周计算缺氧暴露的累积量（cT 或氧饱和度<80%），并对结果进行比较。主要结局为需要治疗的 ROP 的发生。
缺氧暴露的累积量与需要治疗的 ROP 显著相关。在调整了其他新生儿合并症后，只有胎龄与需要治疗的 ROP 始终相关。
在调整了混杂因素后，出生后最初几周的缺氧暴露累积量与 ROP 或 ROP 的治疗无关。
