Branger B, Dochez V, Gervier S, Winer N
Épidémiologie, 11, bis rue Gabriel-Luneau, 44000 Nantes, France.
Service de gynécologie-obstétrique, CHU, 38, boulevard Jean-Monnet, 44093 Nantes, France.
Gynecol Obstet Fertil Senol. 2018 May;46(5):458-465. doi: 10.1016/j.gofs.2018.03.008. Epub 2018 Apr 12.
The objective of the study is to determine the risk factors for caesarean section at the time of labor induction, to establish a prediction algorithm, to evaluate its relevance and to compare the results with observation.
A retrospective study was carried out over a year at Nantes University Hospital with 941 cervical ripening and labor inductions (24.1%) terminated by 167 caesarean sections (17.8%). Within the cohort, a case-control study was conducted with 147 caesarean sections and 148 vaginal deliveries. A multivariate analysis was carried out with a logistic regression allowing the elaboration of an equation of prediction and an ROC curve and the confrontation between the prediction and the reality.
In univariate analysis, six variables were significant: nulliparity, small size of the mother, history of scarried uterus, use of prostaglandins as a mode of induction, unfavorable Bishop score<6, variety of posterior release. In multivariate analysis, five variables were significant: nulliparity, maternal size, maternal BMI, scar uterus and Bishop score. The most predictive model corresponded to an area under the curve of 0.86 (0.82-0.90) with a correct prediction percentage ("well classified") of 67.6% for a caesarean section risk of 80%.
The prediction criteria would make it possible to inform the woman and the couple about the potential risk of Caesarean section in urgency or to favor a planned Caesarean section or a low-lying attempt on more objective, repeatable and transposable arguments in a medical team.
本研究的目的是确定引产时剖宫产的危险因素,建立预测算法,评估其相关性,并将结果与观察结果进行比较。
在南特大学医院进行了为期一年的回顾性研究,941例宫颈成熟和引产(占24.1%)中有167例以剖宫产结束(占17.8%)。在该队列中,进行了一项病例对照研究,包括147例剖宫产和148例阴道分娩。采用逻辑回归进行多变量分析,从而得出预测方程和ROC曲线,并将预测结果与实际情况进行对比。
单变量分析中,六个变量具有显著性:初产、母亲身材矮小、有子宫瘢痕史、使用前列腺素作为引产方式、Bishop评分<6、后位释放类型。多变量分析中,五个变量具有显著性:初产、母亲身材、母亲BMI、瘢痕子宫和Bishop评分。最具预测性的模型对应的曲线下面积为0.86(0.82 - 0.90),对于剖宫产风险为80%的情况,正确预测百分比(“分类良好”)为67.6%。
这些预测标准能够让产妇及其伴侣了解紧急剖宫产的潜在风险,或者基于医疗团队中更客观、可重复和可推广的依据,支持计划剖宫产或低位分娩尝试。