Serruys P W, Juilliere Y, Bertrand M E, Puel J, Rickards A F, Sigwart U
Catheterization Laboratory, Erasmus University, Rotterdam, The Netherlands.
Am J Cardiol. 1988 May 9;61(14):71G-76G. doi: 10.1016/s0002-9149(88)80036-5.
The purpose of this study was to assess the early changes in stenosis geometry after insertion of intravascular stents in human coronary arteries. Morphologic changes were evaluated by quantitative coronary angiography (using automated edge detection) and by calculation of the theoretical pressure decrease across the dilated and stented stenosis from the Poiseuille and turbulent resistances assuming a coronary blood flow of either 1 or 3 ml/s. Twenty-six patients were studied before and after angioplasty, as well as immediately after stent implantation. The stented coronary artery was the left anterior descending artery in 19 cases, the circumflex artery in 2 cases, the right coronary artery in 2 cases and a coronary artery bypass vein graft in 3 cases. After stent implantation, an additional increase in minimal luminal cross-sectional area of the dilated vessel was observed, suggesting that the self-expanding stainless steel endoprosthesis used in this study has a dilating function in addition to its stenting role.
本研究的目的是评估人类冠状动脉内植入血管支架后狭窄几何形状的早期变化。通过定量冠状动脉造影(使用自动边缘检测)以及根据泊肃叶定律和湍流阻力计算扩张和植入支架后狭窄处的理论压力下降来评估形态学变化,假设冠状动脉血流量为1或3 ml/s。对26例患者在血管成形术前、术后以及支架植入后立即进行了研究。植入支架的冠状动脉中,左前降支19例,回旋支2例,右冠状动脉2例,冠状动脉搭桥静脉移植物3例。支架植入后,观察到扩张血管的最小管腔横截面积进一步增加,表明本研究中使用的自膨胀不锈钢内置假体除了具有支架作用外,还具有扩张功能。