电化学脱氢环化 1,3-二羰基化合物。
Electrochemical dehydrogenative cyclization of 1,3-dicarbonyl compounds.
机构信息
State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory of Chemical Biology of Fujian Province, Innovative Collaboration Center of Chemistry for Energy Materials, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China.
出版信息
Chem Commun (Camb). 2018 May 1;54(36):4601-4604. doi: 10.1039/c8cc02472c.
The intramolecular C(sp3)-H/C(sp2)-H cross-coupling of 1,3-dicarbonyl compounds has been achieved through Cp2Fe-catalyzed electrochemical oxidation. The key to the success of these dehydrogenative cyclization reactions is the selective activation of the acidic α-C-H bond of the 1,3-dicarbonyl moiety to generate a carbon-centered radical.
通过 Cp2Fe 催化的电化学氧化，实现了 1,3-二羰基化合物的分子内 C(sp3)-H/C(sp2)-H 交叉偶联。这些脱氢环化反应成功的关键在于选择性地活化 1,3-二羰基部分的酸性 α-C-H 键，生成碳中心自由基。
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