全基因组关联研究证实，染色体 Z 上存在一个负责控制洪山鸡无冠性状的区域。
Genome-wide association study confirms that the chromosome Z harbours a region responsible for rumplessness in Hongshan chickens.
机构信息
National Engineering Laboratory for Animal Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Hubei Academy of Agricultural Sciences/Hubei Key Laboratory of Animal Embryonic Engineering and Molecular Breeding, Institute of Animal Husbandry and Veterinary Science, Wuhan, Hubei Province, 430064, China.
出版信息
Anim Genet. 2018 Aug;49(4):326-328. doi: 10.1111/age.12664. Epub 2018 Apr 19.
Rumplessness in Hongshan chickens has been reported as a novel sex-linked characteristic. Re-sequencing data suggest that a pseudogene on the Z chromosome, LOC431648, is affiliated with this phenotype. In this study, we chose 23 rumpless and 25 normal Hongshan chickens to localize the potential variation by means of a genome-wide association study using a high density microarray. A region on the Z chromosome was found to be closely associated with rumplessness in Hongshan chickens. The region, located in gene LINGO2, was approximately 3 Mb away from pseudogene LOC431648. The function of this gene has not yet been studied in birds. Differential expression of the candidate genes in the tail feather follicles was not detected by q-PCR, which suggests that the rumplessness trait could be attributed to other genetic mechanisms.
红山鸡的无尾性状被报道为一种新的性连锁特征。重测序数据表明，Z 染色体上的一个假基因 LOC431648 与这种表型有关。在这项研究中，我们选择了 23 只无尾和 25 只正常的红山鸡，通过使用高密度微阵列的全基因组关联研究来定位潜在的变异。在 Z 染色体上发现了一个与红山鸡无尾性状密切相关的区域。该区域位于基因 LINGO2 内，距离假基因 LOC431648 约 3 Mb。这个基因在鸟类中的功能尚未被研究过。q-PCR 未检测到候选基因在尾羽毛囊中的差异表达，这表明无尾性状可能归因于其他遗传机制。
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