Larsson Anette, Palstam Annie, Bjersing Jan, Löfgren Monika, Ernberg Malin, Kosek Eva, Gerdle Björn, Mannerkorpi Kaisa
Institute of Neuroscience and Physiology, Section of Health and Rehabilitation, Physiotherapy, Sahlgrenska Academy, University of Gothenburg, Box 430, 40530, Gothenburg, Sweden.
University of Gothenburg Centre for Person-Centred Care (GPCC), Gothenburg, Sweden.
BMC Musculoskelet Disord. 2018 Apr 19;19(1):121. doi: 10.1186/s12891-018-2047-1.
Health and physical capacity are commonly associated with disease, age, and socioeconomic factors. The primary objective of this study was to investigate the degree to which physical capacity, defined as muscle strength and walking ability, is decreased in women with fibromyalgia (FM), as compared to healthy women, who are matched for age and level of education. The secondary aim was to investigate whether muscle strength and walking ability are associated with age, symptom duration, activity limitations and, Body Mass Index (BMI) in women with FM and control subjects.
This controlled, cross-sectional, multi-center study comprised 118 women with FM and 93 age- and education-level-matched healthy women. The outcome measures were isometric knee-extension force, isometric elbow-flexion force, isometric hand-grip force, and walking ability. Differences between the groups were calculated, and for the women with FM analyses of correlations between the measures of physical capacity and variables were performed.
The women with FM showed 20% (p < 0.001) lower isometric knee-extension force, 36% (p < 0.001) lower isometric elbow-flexion force, 34% (p < 0.001) lower isometric hand-grip force, and 16% lower walking ability (p < 0.001), as compared to the healthy controls. All measures of muscle strength in women with FM showed significant weak to moderate relationship to symptom duration (r = - 0.23-0.32) and walking ability (r = 0.25-0.36). Isometric knee-extension force correlated with activity limitations, as measured using the SF-36 Physical function subscale (r0.23, p = 0.011).
Physical capacity was considerably decreased in the women with FM, as compared to the age- and education-level-matched control group. All measures of physical capacity showed a significant association with symptom duration. Knee-extension force and walking ability were significantly associated with activity limitations, age, and BMI. It seems important to address this problem and to target interventions to prevent decline in muscle strength. Assessments of muscle strength and walking ability are easy to administer and should be routinely carried out in the clinical setting for women with FM.
ClinicalTrials.gov identification number: NCT01226784 , Oct 21, 2010.
健康状况和身体能力通常与疾病、年龄及社会经济因素相关。本研究的主要目的是调查与年龄和教育程度相匹配的健康女性相比，纤维肌痛（FM）女性的身体能力（定义为肌肉力量和行走能力）下降的程度。次要目的是调查FM女性和对照受试者的肌肉力量及行走能力是否与年龄、症状持续时间、活动受限情况和体重指数（BMI）相关。
这项对照、横断面、多中心研究纳入了118名FM女性和93名年龄及教育程度相匹配的健康女性。观察指标为等长伸膝力量、等长屈肘力量、等长握力和行走能力。计算两组之间的差异，并对FM女性进行身体能力测量指标与各变量之间的相关性分析。
与健康对照组相比，FM女性的等长伸膝力量降低了20%（p<0.001），等长屈肘力量降低了36%（p<0.001），等长握力降低了34%（p<0.001），行走能力降低了16%（p<0.001）。FM女性的所有肌肉力量测量指标均显示与症状持续时间（r=-0.23-0.32）和行走能力（r=0.25-0.36）存在显著的弱至中度相关性。等长伸膝力量与使用SF-36身体功能分量表测量的活动受限情况相关（r=0.23，p=0.011）。
与年龄和教育程度相匹配的对照组相比，FM女性的身体能力显著下降。所有身体能力测量指标均与症状持续时间存在显著相关性。伸膝力量和行走能力与活动受限情况、年龄和BMI显著相关。解决这一问题并针对性地进行干预以防止肌肉力量下降似乎很重要。肌肉力量和行走能力的评估易于实施，应在临床环境中对FM女性进行常规评估。
ClinicalTrials.gov标识符：NCT01226784，2010年10月21日。
