School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
Department of Radiology, The Second Hospital of Jilin University, Changchun 130041, PR China.
Talanta. 2018 Jul 1;184:461-467. doi: 10.1016/j.talanta.2018.03.018. Epub 2018 Mar 14.
Nowadays, in order to improve the diagnostic accuracy of the disease, more and more contrast agents have been applied in the clinical imaging modalities. A combination of nanotechnology with optical, computed X-ray tomography (CT), and magnetic resonance imaging (MRI) has great potential to improve disease diagnosis and therapy. Herein, we developed a novel multimodal contrast agent for deep-tissue bioimaging based on PEGylated Mn doped NaLuF:Yb/Er nanoparticles (PEG-UCNPs). The multimodal nanoprobes have revealed the intensely red upconversion luminescence emission for deep-tissue upconversion luminescence (UCL) imaging. Moreover, Owing to the high longitudinal relaxivity, the PEG-UCNPs can be used as T-weighted MRI contrast agents. Additionally, with the high X-ray mass absorption coefficient of Lu, the novel nanoprobes are appropriate for CT imaging. With integration the high paramagnetic property, superior X-ray mass absorption coefficient and excellent upconversion luminescence in one system, the multimodal nanoprobes can provide a unique opportunity for MRI, CT and UCL imaging. More importantly, modification with PEG endows the novel nanoprobes with high biocompatibility, which would bring more opportunities for the biomedical applications in clinic.
如今，为了提高疾病的诊断准确性，越来越多的造影剂被应用于临床成像模式。将纳米技术与光学、计算机 X 射线断层扫描（CT）和磁共振成像（MRI）相结合，具有极大的潜力来改善疾病的诊断和治疗。在这里，我们开发了一种基于聚乙二醇化 Mn 掺杂 NaLuF:Yb/Er 纳米粒子（PEG-UCNPs）的新型用于深部组织生物成像的多模式造影剂。多模式纳米探针显示出强烈的上转换发光发射，可用于深部组织上转换发光（UCL）成像。此外，由于具有较高的纵向弛豫率，PEG-UCNPs 可用作 T1 加权 MRI 造影剂。此外，由于 Lu 具有较高的 X 射线质量吸收系数，新型纳米探针适用于 CT 成像。新型纳米探针将高顺磁性、优异的 X 射线质量吸收系数和优异的上转换发光性能集成在一个系统中，为 MRI、CT 和 UCL 成像提供了独特的机会。更重要的是，聚乙二醇的修饰赋予了新型纳米探针良好的生物相容性，这将为临床的生物医学应用带来更多机会。
