Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Imaging Institute and Cancer Biology Department, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
J Nucl Med. 2018 Jul;59(7):1007-1013. doi: 10.2967/jnumed.117.203877. Epub 2018 Apr 19.
In this review, we cover the evolution of knowledge on the biology of prostate-specific membrane antigen (PSMA) and its translation to therapy. The usual key to discovery is a realistic model for experimentation and for testing a hypothesis. A realistic model is especially needed in the case of the human prostate, which differs significantly from the prostate of species often used as research models. We will emphasize the genetic characterization of PSMA, the nature of the PSMA protein, and its role as a carboxypeptidase, with differing important substrates and products in different tissues. We give special prominence to the importance of PSMA as a target for imaging and therapy in prostate cancer and its underdeveloped role for imaging and targeting the neovasculature of tumors other than prostate cancer. Lastly, we bring attention to its importance in other nonprostatic tissues.
在这篇综述中，我们介绍了前列腺特异性膜抗原（PSMA）的生物学知识的发展及其向治疗学的转化。通常，发现的关键是一个用于实验和检验假设的现实模型。在人类前列腺的情况下，尤其需要这样一个现实模型，因为它与通常用作研究模型的物种的前列腺有很大的不同。我们将强调 PSMA 的遗传特征、PSMA 蛋白的性质及其作为羧肽酶的作用，不同组织中具有不同的重要底物和产物。我们特别强调 PSMA 作为前列腺癌成像和治疗靶点的重要性，以及其在成像和靶向除前列腺癌以外的肿瘤新生血管方面的未充分发挥的作用。最后，我们提请注意它在其他非前列腺组织中的重要性。
