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角膜纤维瘤:一种不常见的基质肿瘤。

Corneal fibroma: An uncommon stromal tumor.

机构信息

Mehta Eye Clinic, Ghatkopar, Mumbai; Ophthalmic Plastic Surgery & Ocular Oncology Services, Advanced Eye Hospital & Institute, Navi Mumbai, India.

Mehta Eye Clinic, Ghatkopar, Mumbai, India.

出版信息

Indian J Ophthalmol. 2018 May;66(5):699-701. doi: 10.4103/ijo.IJO_936_17.

Abstract

A 56-year-old male patient presented with a slow-growing, elevated, smooth, white corneal mass. The mass was excised by performing an alcohol-assisted keratoepitheliectomy and sent for histopathological examination. Subepithelially, closely packed spindle cells in "feather-stitched" or storiform pattern were seen. Immunohistochemically, the cells stained negatively for CD-34 and S-100 and focal positivity was seen for vimentin. Based on the morphology and immunochemical staining, a diagnosis of corneal fibroma was made. No recurrence was seen. Corneal fibroma is an exceedingly rare, benign tumor and possibly lies on the same spectrum as corneal keloid and hypertrophic cicatrix. Surgical resection is usually curative.

摘要

一位 56 岁男性患者因生长缓慢、隆起、光滑、白色的角膜肿块就诊。通过施行酒精辅助的角膜上皮切除术切除该肿块,并将其送检作组织病理学检查。在角膜上皮下,可见呈“羽毛状”或席纹状排列的紧密堆积的梭形细胞。免疫组化染色显示,细胞 CD-34 和 S-100 染色阴性,波形蛋白呈局灶性阳性。根据形态学和免疫化学染色,诊断为角膜纤维瘤。未见复发。角膜纤维瘤是一种极为罕见的良性肿瘤,可能与角膜瘢痕疙瘩和肥厚性瘢痕处于同一谱系。手术切除通常可治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/062d/5939170/026f29b2f6c8/IJO-66-699-g001.jpg

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