[Comparison of the prevalence of chronic kidney disease in patients of the Emergency Department of the Regional Hospital in Kielce based on GFR estimation according abbreviated MDRD formula or CKD-EPI equation].

INTRODUCTION

Glomerular filtration rate plays a key role in the diagnosis of chronic kidney disease (CKD). In everyday practice GFR is estimated using equations based on serum creatinine. Commonly used abbreviated MDRD formula is not very precise in patients with mildly impaired renal function, underestimating eGFR when greater than 60 ml/min/1.73 m2. CKD-EPI formula, recommended by KDIGO, might be a good alternative in this situation. The aim of the study was to compare the prevalence of consecutive stages of CKD in the group of patients from Emergency Department having calculated eGFR according MDRD and CKD-EPI formulas

MATERIALS AND METHODS

The retrospective study was performed in the group of 1,452 patients (762 women and 690 men aged 57.4 years ± 19.8 years). Estimated GFR (eGFR) was calculated based on MDRD and CKD-EPI formulas and the obtained results were analyzed according patients location in the consecutive group of CKD, used formulas, sex and age.

RESULTS

The mean values of eGFR for both formulas were similar and for MDRD was 68.6 ± 22.3 ml/min/ 1.73 m2 while for CKD-EPI 69.18 ± 24.4 ml/ min/1.73 m2. The highest differences were observed in the early stages of CKD where the calculation of eGFR based on CKD-EPI vs MDRD formula gives an increase of population in stage G1 of CKD by 5.7% (342 vs 241 persons) and reduction by 7.8% (625 vs 737) in the stage G2.

CONCLUSIONS

Both formulas have the similar value in the estimation of CKD. The differences concerning mainly G1 and G2 stages.