Epidemiology and Applied Research Branch, Division of Cancer and Prevention, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA.
Epidemiology and Applied Research Branch, Division of Cancer and Prevention, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA; Epidemic Intelligence Service, CDC, Atlanta, GA.
Ann Epidemiol. 2018 May;28(5):328-330. doi: 10.1016/j.annepidem.2018.03.001. Epub 2018 Mar 6.
Current literature shows different findings on the contemporary trends of distant-stage prostate cancer incidence, in part, due to low study population coverage and wide age groupings. This study aimed to examine the stage-specific incidence rates and trends of prostate cancer by age (5-year grouping), race, and ethnicity using nationwide cancer registry data.
Data on prostate cancer cases came from the 2004-2014 United States Cancer Statistics data set. We calculated stage-specific incidence and 95% confidence intervals by age (5-year age grouping), race, and ethnicity. To measure the changes in rates over time, we calculated annual percentage change (APC).
We identified 2,137,054 incident prostate cancers diagnosed during 2004-2014, with an age-adjusted incidence rate of 453.8 per 100,000. Distant-stage prostate cancer incidence significantly decreased during 2004-2010 (APC = -1.2) and increased during 2010-2014 (APC = 3.3). Significant increases in distant prostate cancer incidence also occurred in men aged older than or equal to 50 years except men aged 65-74 and older than or equal to 85 years, in men with white race (APC = 3.9), and non-Hispanic ethnicity (APC = 3.5).
Using data representing over 99% of U.S. population, we found that incidence rates of distant-stage prostate cancer significantly increased during 2010-2014 among men in certain ages, in white, and with non-Hispanic ethnicity.
目前的文献显示，由于研究人群覆盖范围低和年龄分组广泛，当代前列腺癌远处转移阶段发病率的趋势存在不同的结果。本研究旨在使用全国癌症登记数据，通过年龄（5 年分组）、种族和族裔检查前列腺癌的特定分期发病率和趋势。
前列腺癌病例数据来自 2004-2014 年美国癌症统计数据。我们按年龄（5 年年龄分组）、种族和族裔计算了特定分期的发病率和 95%置信区间。为了衡量随时间变化的发病率变化，我们计算了年百分比变化（APC）。
我们确定了 2137054 例在 2004-2014 年间诊断的前列腺癌病例，年龄调整后的发病率为 453.8/100000。2004-2010 年间远处转移前列腺癌的发病率显著下降（APC=-1.2），2010-2014 年间发病率增加（APC=3.3）。除了年龄在 65-74 岁及以上和 85 岁及以上的男性外，年龄在 50 岁及以上的男性、白人男性（APC=3.9）和非西班牙裔男性（APC=3.5）的远处前列腺癌发病率也显著增加。
使用代表超过 99%的美国人口的数据，我们发现 2010-2014 年间，在某些年龄、白人、非西班牙裔人群中，远处转移阶段前列腺癌的发病率显著增加。
