下颌前伸改变成年小鼠髁突中I型胶原蛋白、骨钙素和骨连接蛋白的基因表达。
Mandible protraction alters Type I collagen, osteocalcin and osteonectin gene expression in adult mice condyle.
作者信息
Valerio Patricia, Perfeito Filipi, Moura Livia P, Ribeiro Deborah N, Fernandes Simone O A, Martins Almir S, Leite Maria F
机构信息
Department of Physiology and Biophysics, Federal University of Minas Gerais, Brazil.
School of Pharmacy, Federal University of Minas Gerais, Brazil.
出版信息
Ann Stomatol (Roma). 2018 Mar 8;8(3):95-103. doi: 10.11138/ads/2017.8.3.095. eCollection 2017 Sep-Dec.
Mandible condyle remodeling is a great challenge on craniofacial growth studies. The great majority of the reports deals with growing period. However, there is a great necessity to clarify the importance of functional stimulation on adult mandible condyle remodeling. By using an adult mouse model, we investigated the influence of mandible forwarding on condyle remodeling and gene expression by bone forming cells. Tomographic and scintigraphic evaluations showed sagittal growth and cell activity enhancement. RT-PCR showed that Type I collagen, osteocalcin and osteonectin expression level can be altered. We showed that functional stimulation is necessary to maintain the regular gene expression by condyle bone forming cells in adult mice. It opens new frame for further investigations aiming new clinical approaches to temporomandibular joint problems treatment, as well as mandible retrusion treatment.
下颌髁突重塑是颅面生长研究中的一大挑战。绝大多数报告涉及生长发育期。然而，非常有必要阐明功能刺激对成年下颌髁突重塑的重要性。通过使用成年小鼠模型，我们研究了下颌前伸对髁突重塑及成骨细胞基因表达的影响。断层扫描和闪烁扫描评估显示矢状生长和细胞活性增强。逆转录聚合酶链反应表明I型胶原、骨钙素和骨连接蛋白的表达水平会发生改变。我们表明，功能刺激对于成年小鼠髁突成骨细胞维持正常基因表达是必要的。这为进一步研究开辟了新的框架，旨在探索治疗颞下颌关节问题以及下颌后缩的新临床方法。
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