Department of Pathology and Laboratory Medicine, King Hussein Cancer Center, 202 Queen Rania Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Department of Surgery, King Hussein Cancer Center, Amman, Jordan.
Breast Cancer. 2018 Sep;25(5):597-604. doi: 10.1007/s12282-018-0860-x. Epub 2018 Apr 24.
Breast cancer is one of the most prevalent cancers in women. Oncotype Dx is a multi-gene assay frequently used to predict the recurrence risk for estrogen receptor-positive early breast cancer, with values < 18 considered low risk; ≥ 18 and ≤ 30, intermediate risk; and > 30, high risk. Patients at a high risk for recurrence are more likely to benefit from chemotherapy treatment.
In this study, clinicopathological parameters for 37 cases of early breast cancer with available Oncotype Dx results were used to estimate the recurrence score using the three new Magee equations. Correlation studies with Oncotype Dx results were performed. Applying the same cutoff points as Oncotype Dx, patients were categorized into low-, intermediate- and high-risk groups according to their estimated recurrence scores.
Pearson correlation coefficient (R) values between estimated and actual recurrence score were 0.73, 0.66, and 0.70 for Magee equations 1, 2 and 3, respectively. The concordance values between actual and estimated recurrence scores were 57.6%, 52.9%, and 57.6% for Magee equations 1, 2 and 3, respectively. Using standard pathologic measures and immunohistochemistry scores in these three linear Magee equations, most low and high recurrence risk cases can be predicted with a strong positive correlation coefficient, high concordance and negligible two-step discordance.
Magee equations are user-friendly and can be used to predict the recurrence score in early breast cancer cases.
乳腺癌是女性最常见的癌症之一。Oncotype Dx 是一种常用于预测雌激素受体阳性早期乳腺癌复发风险的多基因检测方法，其值<18 被认为是低风险；≥18 且≤30 为中风险；>30 为高风险。复发风险高的患者更有可能从化疗治疗中获益。
本研究使用 37 例早期乳腺癌患者的临床病理参数和可获得的 Oncotype Dx 结果，应用三种新的 Magee 方程来估计复发评分。对 Oncotype Dx 结果进行了相关性研究。应用与 Oncotype Dx 相同的截断点，根据估计的复发评分将患者分为低风险、中风险和高风险组。
Magee 方程 1、2 和 3 估计的复发评分与实际复发评分的 Pearson 相关系数（R）值分别为 0.73、0.66 和 0.70。Magee 方程 1、2 和 3 的实际和估计复发评分的一致性值分别为 57.6%、52.9%和 57.6%。使用这三个线性 Magee 方程中的标准病理测量和免疫组化评分，可以预测大多数低和高复发风险病例，具有很强的正相关系数、高一致性和可忽略的两步不一致性。
Magee 方程易于使用，可用于预测早期乳腺癌病例的复发评分。
