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无脑膜炎的侵袭性脑膜炎球菌病:一种被遗忘的诊断。

Invasive meningococcal disease without meningitis: a forgotten diagnosis.

作者信息

Walayat Saqib, Hussain Nooreen, Malik Abdullah H, Vazquez-Melendez Elsa, Aulakh Bhagat S, Lynch Teresa

机构信息

Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

Department of Pulmonary/Critical Care Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.

出版信息

Int Med Case Rep J. 2018 Apr 12;11:87-90. doi: 10.2147/IMCRJ.S154807. eCollection 2018.

Abstract

, a Gram-negative diplococcus, is an uncommon cause of pneumonia. There have been only about 344 cases reported worldwide from 1906 to 2015. To our knowledge, there have been only 3 cases reported in the USA in the past 2 decades. We present a case of a 72-year-old male with a past medical history of severe COPD, obstructive sleep apnea, and stage I lung cancer status post-stereotactic body radiation therapy 1 year ago, who was admitted with a 6-day history of productive cough with yellowish sputum, shortness of breath, extreme myalgias, and fatigue. Chest X-ray revealed an infiltrative process in the left lower lung field and left-sided pleural effusion. Blood cultures grew beta-lactamase-negative after 24 hours. Our patient was initially treated with broad-spectrum antibiotics, which were later switched to amoxicillin to complete a total of 14 days of antibiotics. Diagnosing meningococcal pneumonia requires a high level of suspicion, as sputum cultures may be falsely positive due to asymptomatic carriage of the organism in the upper respiratory tract in up to 10% of outpatient population. We highlight this case as early recognition and treatment is critical. The case fatality rate for pneumonia has been reported to be higher compared with meningococcal meningitis.

摘要

革兰氏阴性双球菌是肺炎的一种罕见病因。从1906年到2015年,全球仅报告了约344例病例。据我们所知,在过去20年中,美国仅报告了3例。我们报告一例72岁男性患者,既往有严重慢性阻塞性肺疾病、阻塞性睡眠呼吸暂停病史,1年前接受立体定向体部放射治疗后处于I期肺癌状态,因咳嗽、咳黄色痰6天、气短、极度肌痛和疲劳入院。胸部X线显示左下肺野浸润性病变及左侧胸腔积液。血培养24小时后培养出β-内酰胺酶阴性的[具体细菌名称未给出]。我们的患者最初接受广谱抗生素治疗,后来改用阿莫西林,共使用抗生素14天。诊断脑膜炎球菌性肺炎需要高度怀疑,因为在高达10%的门诊人群中,由于该菌在上呼吸道无症状携带,痰培养可能出现假阳性。我们强调该病例,因为早期识别和治疗至关重要。据报道,脑膜炎球菌性肺炎的病死率高于脑膜炎球菌性脑膜炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82eb/5905520/ea06454600f4/imcrj-11-087Fig1.jpg

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