Zhou Mi, Jiang Bo, Xiong Mao, Zhu Xin
Department of Respiratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Physiol. 2018 Apr 11;9:377. doi: 10.3389/fphys.2018.00377. eCollection 2018.
Cancer remains a leading cause of death and constitutes an enormous burden on society worldwide. The association between the human telomerase reverse transcriptase (TERT) gene variant rs2736098 polymorphisms and cancer predisposition remain inconclusive. Databases including Pubmed and Embase were systematically searched from inception to September 15, 2017 to retrieve studies investigating the association between the TERT variant rs2736098 polymorphisms and cancer risk in accordance with previously determined exclusion and inclusion criteria. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were evaluated using random or fixed effects models. Thirty-one case-control studies from 29 articles with 15,837 cases and 19,263 controls were screened out after a systematic search. Pooled analysis demonstrated that the TERT variant rs2736098 G > A polymorphism was significantly correlated with cancer risk in all populations (A vs. G: OR = 1.134, 95% CI = 1.051-1.224, = 0.001; AA vs. GG: OR = 1.280, 95% CI = 1.087-1.508, = 0.003; GA vs. GG: OR = 1.125, 95% CI = 1.020-1.240, = 0.018; GA/AA vs. GG: OR = 1.159, 95% CI = 1.047-1.283, = 0.004). In the subgroup analysis based on cancer type, the TERT rs2736098 with the A allele was 1.299 times more frequent than that with the G allele (OR = 1.299, 95% CI = 1.216-1.386) under the allelic genetic model in lung cancer, and 1.152 times (OR = 1.152, 95% CI = 1.032-1.286) that in bladder cancer. This meta-analysis demonstrated significant correlations between the TERT variant rs2736098 polymorphisms and cancer susceptibility. The A allele in the rs2736098 G > A polymorphism contributes to susceptibility in many types of cancer, especially lung cancer and bladder cancer.
癌症仍然是主要的死亡原因，给全球社会带来了巨大负担。人类端粒酶逆转录酶（TERT）基因变体rs2736098多态性与癌症易感性之间的关联尚无定论。系统检索了包括Pubmed和Embase在内的数据库，检索时间从建库至2017年9月15日，以检索根据先前确定的排除和纳入标准，研究TERT变体rs2736098多态性与癌症风险之间关联的研究。使用随机或固定效应模型评估合并比值比（OR）和相应的95%置信区间（CI）。经过系统检索，从29篇文章中筛选出31项病例对照研究，共15837例病例和19263例对照。合并分析表明，TERT变体rs2736098 G>A多态性在所有人群中均与癌症风险显著相关（A与G相比：OR = 1.134，95%CI = 1.051-1.224，P = 0.001；AA与GG相比：OR = 1.280，95%CI = 1.087-1.508，P = 0.003；GA与GG相比：OR = 1.125，95%CI = 1.020-1.240，P = 0.018；GA/AA与GG相比：OR = 1.159，95%CI = 1.047-1.283，P = 0.004）。在基于癌症类型的亚组分析中，在肺癌的等位基因遗传模型下，携带A等位基因的TERT rs2736098比携带G等位基因的频率高1.299倍（OR = 1.299，95%CI = 1.216-1.386），在膀胱癌中高1.152倍（OR = 1.152，95%CI = 1.032-1.286）。这项荟萃分析表明TERT变体rs2736098多态性与癌症易感性之间存在显著关联。rs2736098 G>A多态性中的A等位基因在多种癌症类型中导致易感性增加，尤其是肺癌和膀胱癌。
