Wen Yong, Shi Lei, Li Jun, Du Weiliang, Chen Ye, Lan Xiaolin
Department of TCM, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China.
Zhongguo Zhen Jiu. 2018 Apr 12;38(4):353-7. doi: 10.13703/j.0255-2930.2018.04.003.
To observe the efficacy of acupuncture combined with acupoint catgut embedding sequential therapy and medication for mild and moderate ulcerative colitis.
One hundred and twenty patients were randomized into an acupuncture and acupoint catgut embedding sequential therapy group (a combination group) and a mesalazine group, 60 cases in each one. Fifty-seven cases in the combination group and 55 cases in the mesalazine group were included into analysis. In the combination group, acupuncture was applied at Tianshu (ST 25), Shangjuxu (ST 37), Quchi (LI 11) during the activity period, and acupoint catgut embedding was applied at Pishu (BL 20), Zusanli (ST 36), Guanyuan (CV 4) during the alleviate period. The patients in the mesalazine group were treated with mesalazine orally. The treatment was given for 12 weeks. The scores of TCM symptoms, colonoscopy, mucosa healing rate were compared before and after treatment in the two groups. The effects, adverse reactions and the recurrent rates during 1-year follow-up were observed.
After treatment, the scores of TCM symptoms decreased in the two groups (both <0.05), and the result in the combination group was better than that in the mesalazine group (<0.05). The total effective rate in the combination group was 87.7% (50/57), which was better than 70.9% (39/55) in the mesalazine group (<0.05). The colonoscopy scores decreased after treatment in the two groups (both <0.05). There was no significant difference between the two groups on colonoscopy score and mucosal healing rate [50.9% (29/57) vs 34.5% (19/55), both >0.05]. The recurrent rate in the combination group was 8.5% (4/47)，which was lower than 32.4% (11/34) in the mesalazine group (<0.05). No severe adverse reaction was found during the treatment in the two groups.
Acupuncture combined with acupoint catgut embedding sequential therapy can improve mild and moderate ulcerative colitis and reduce the recurrent rate.
观察针刺联合穴位埋线序贯疗法与药物治疗轻中度溃疡性结肠炎的疗效。
将120例患者随机分为针刺联合穴位埋线序贯疗法组（联合组）和美沙拉嗪组，每组60例。联合组纳入分析57例，美沙拉嗪组纳入分析55例。联合组在活动期针刺天枢（ST25）、上巨虚（ST37）、曲池（LI11），缓解期穴位埋线脾俞（BL20）、足三里（ST36）、关元（CV4）。美沙拉嗪组患者口服美沙拉嗪治疗。治疗12周。比较两组治疗前后中医症状评分、结肠镜检查、黏膜愈合率。观察疗效、不良反应及1年随访期内的复发率。
治疗后，两组中医症状评分均降低（均P<0.05），且联合组效果优于美沙拉嗪组（P<0.05）。联合组总有效率为87.7%（50/57），优于美沙拉嗪组的70.9%（39/55）（P<0.05）。两组治疗后结肠镜评分均降低（均P<0.05）。两组结肠镜评分及黏膜愈合率比较差异无统计学意义[50.9%（29/57）比34.5%（19/55），均P>0.05]。联合组复发率为8.5%（4/47），低于美沙拉嗪组的32.4%（ll/34）（P<0.05）。两组治疗期间均未发现严重不良反应。
针刺联合穴位埋线序贯疗法可改善轻中度溃疡性结肠炎并降低复发率。
