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神经重症监护病房的发展,更广泛地关注所有有脑损伤风险的新生儿:头 2 年。

Development of a NeuroNICU with a Broader Focus on All Newborns at Risk of Brain Injury: The First 2 Years.

机构信息

Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.

Department of Neonatology, Lucile Packard Children's Hospital Stanford, Palo Alto, California.

出版信息

Am J Perinatol. 2018 Oct;35(12):1197-1205. doi: 10.1055/s-0038-1646954. Epub 2018 Apr 27.

Abstract

OBJECTIVE

Many critically ill neonates have an existing brain injury or are at risk of neurologic injury. We developed a "NeuroNICU" (neurologic neonatal intensive care unit) to better provide neurologically focused intensive care.

STUDY DESIGN

Demographic and clinical variables, services delivered, and patient outcomes were recorded in a prospective database for all neonates admitted to the NeuroNICU between April 23, 2013, and June 25, 2015.

RESULTS

In total, 546 neonates were admitted to the NeuroNICU representing 32% of all NICU admissions. The most common admission diagnoses were congenital heart disease (30%), extreme prematurity (18%), seizures (10%), and hypoxic-ischemic encephalopathy (9%). Neuromonitoring was common, with near-infrared spectroscopy used in 69%, amplitude-integrated electroencephalography (EEG) in 45%, and continuous video EEG in 35%. Overall, 43% received neurology or neurosurgery consultation. Death prior to hospital discharge occurred in 11%. Among survivors, 87% were referred for developmental follow-up, and among those with a primary neurologic diagnosis 57% were referred for neurology or neurosurgical follow-up.

CONCLUSION

The NeuroNICU-admitted newborns with or at risk of brain injury comprise a high percentage of NICU volume; 38% had primary neurologic diagnoses, whereas 62% had medical diagnoses. We found many opportunities to provide brain focused intensive care, impacting a substantial proportion of newborns in our NICU.

摘要

目的

许多危重新生儿存在现有脑损伤或存在神经损伤风险。我们开发了一个“神经新生儿重症监护病房(NeuroNICU)”,以更好地提供专注于神经的重症护理。

研究设计

在 2013 年 4 月 23 日至 2015 年 6 月 25 日期间,所有进入 NeuroNICU 的新生儿均在一个前瞻性数据库中记录人口统计学和临床变量、提供的服务和患者结局。

结果

共有 546 名新生儿被收入 NeuroNICU,占新生儿重症监护病房总入院人数的 32%。最常见的入院诊断为先天性心脏病(30%)、极早产儿(18%)、癫痫发作(10%)和缺氧缺血性脑病(9%)。神经监测很常见,近红外光谱(NIRS)使用率为 69%,振幅整合脑电图(aEEG)为 45%,连续视频脑电图(cEEG)为 35%。总体而言,43%的患者接受了神经科或神经外科会诊。出院前死亡的有 11%。幸存者中,87%被转介进行发育随访,其中原发性神经诊断的有 57%被转介进行神经科或神经外科随访。

结论

NeuroNICU 收治的有或有脑损伤风险的新生儿占新生儿重症监护病房容量的很大比例;38%有原发性神经诊断,而 62%有医学诊断。我们发现了许多提供脑专注重症护理的机会,这对我们新生儿重症监护病房的很大一部分新生儿产生了影响。

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