Akashi Tetsuro, Hashimoto Risa, Ohno Akihisa, Matsumoto Kazuhide, Nakamura Yukari
Department of Internal Medicine, Saiseikai Fukuoka General Hospital, Fukuoka, Japan.
Gastroenterology Res. 2018 Apr;11(2):157-160. doi: 10.14740/gr995w. Epub 2018 Apr 7.
The occurrence of diarrhea at the beginning of enteral nutrition complicates the continuation of enteral nutrition. Recently, studies in Japan indicated that diarrhea could be improved by changing the enteral formula to one that is emulsified with egg yolk lecithin. In this study, we administered the enteral formula K-2S plus, which is emulsified with egg yolk lecithin, to 15 patients (four men and 11 women; mean age, 79.9 ± 2.0 years) after they had undergone a percutaneous endoscopic gastrostomy (PEG) to prevent the occurrence of diarrhea related to enteral nutrition. Two days after the PEG, the patients would receive 200 mL K-2S plus intermittently three times daily; thereafter, the amount of K-2S plus was increased according to the patient's condition. The administration rate was scheduled as 200 mL/h when 200 mL were administered at one time. For ≥ 300 mL, the scheduled administration rate was 300 mL/h. When we administered K-2S plus at the beginning of enteral nutrition after the PEG, the dose of the enteral formula could be increased without any occurrence of diarrhea or vomiting. Five patients had received intravenous nutrition before the PEG; thus, we were concerned about diarrhea in these patients. In conclusion, an enteral formula emulsified with egg yolk lecithin may be safely used at the time of enteral nutrition initiation without causing diarrhea.
肠内营养开始时出现腹泻会使肠内营养的持续进行变得复杂。最近,日本的研究表明,将肠内配方改为用蛋黄卵磷脂乳化的配方可改善腹泻情况。在本研究中,我们对15例患者(4名男性和11名女性;平均年龄79.9±2.0岁)在接受经皮内镜下胃造口术(PEG)后给予用蛋黄卵磷脂乳化的肠内配方K-2S plus,以预防与肠内营养相关的腹泻发生。PEG术后两天,患者每天分三次间歇接受200 mL K-2S plus;此后,根据患者情况增加K-2S plus的量。一次给予200 mL时,给药速度设定为200 mL/h。对于≥300 mL,预定给药速度为300 mL/h。当我们在PEG术后肠内营养开始时给予K-2S plus时,肠内配方的剂量可以增加,而不会出现腹泻或呕吐。5例患者在PEG术前接受过静脉营养;因此,我们担心这些患者会出现腹泻。总之,用蛋黄卵磷脂乳化的肠内配方在肠内营养开始时可安全使用,不会引起腹泻。