孕激素制剂的研究进展：一篇综述短文
Research Progress of Progesterone Preparations: A Mini Review.
作者信息
Ye Mingzhu, Pan Weisan, Yang Xinggang, Zhang Xiaoyu
机构信息
Department Pharmaceutical, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Curr Drug Metab. 2018;19(10):871-875. doi: 10.2174/1389200219666180427165438.
BACKGROUND
Progesterone is a sex steroid hormone. Since it has been discovered, it is widely used in the prevention of spontaneous preterm birth, hormone replacement therapy and other gynecological conditions.
METHODS
We will review the progesterone preparations based on a comprehensive study of papers and patents from the traditional preparations up through the very recent literatures.
RESULTS
This review mainly concentrates on oral, vaginal and micro delivery systems, involving different ways to prepare progesterone preparations.
CONCLUSION
Although progesterone has first-pass effects, with these methods, the bioavailability and compliance can be greatly increased.
背景
孕酮是一种性甾体激素。自其被发现以来，它被广泛应用于预防自发性早产、激素替代疗法及其他妇科病症。
方法
我们将基于对从传统制剂到最新文献的论文和专利的全面研究，对孕酮制剂进行综述。
结果
本综述主要集中于口服、阴道及微给药系统，涉及制备孕酮制剂的不同方法。
结论
尽管孕酮有首过效应，但通过这些方法，其生物利用度和顺应性可大幅提高。
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