[Research Progress of Regulation of Hypoxia-mediated Signaling Pathways on Epithelial-Mesenchymal Transition of Tumor Cells].

Hypoxic microenvironment always exists in solid tumors,and it closely relates to the development and metastasis of solid tumor.As a main transcription factor responding to hypoxic environment,hypoxia-inducible factor(HIF)can promote tumor cell proliferation,survival,angiogenesis,and epithelial-mesenchymal transition(EMT),etc.EMT is a biological process that epithelial phenotype was transformed into mesenchymal phenotype,which is mainly associated with its signaling pathways,transcription factors,inflammatory factors and miRNAs,and plays a vital role in tumor invasion and metastasis.This paper summarizes the effects of hypoxia signaling pathway,Wnt/β-catenin signaling pathway,Notch signaling pathway,NF-κB signaling pathway,Hedgehog(Hh)signaling pathway and PI3K/Akt signaling pathway on the EMT of tumor cells.