癌症与脂肪：脂肪组织与肿瘤之间的相互作用
Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors.
作者信息
Lengyel Ernst, Makowski Liza, DiGiovanni John, Kolonin Mikhail G
机构信息
Departments of Obstetrics and Gynecology/Section of Gynecologic Oncology, The University of Chicago, Chicago, IL, USA.
Department of Medicine - Division of Hematology and Oncology, University of Tennessee Health Science Center, Memphis, TN, USA.
出版信息
Trends Cancer. 2018 May;4(5):374-384. doi: 10.1016/j.trecan.2018.03.004. Epub 2018 Apr 5.
Abstract
Obesity has been linked to the increased risk and aggressiveness of many types of carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic stress, may contribute to carcinogenesis and cancer initiation. Evidence that AT plays a role in cancer aggressiveness is solid and mounting. During cancer progression, tumor cells engage in a metabolic symbiosis with adjacent AT. Mature adipocytes provide adipokines and lipids to cancer cells, while stromal and immune cells from AT infiltrate carcinomas and locally secrete paracrine factors within the tumor microenvironment. This review focuses on the crosstalk between AT and tumor cells that promotes tumor growth and increases cellular lipid metabolism, metastasis, and chemoresistance.
摘要
肥胖与多种类型癌症的风险增加及侵袭性增强有关。脂肪组织（AT）中的慢性炎症状态会导致基因毒性应激，这可能有助于致癌作用和癌症的起始。有确凿且越来越多的证据表明，AT在癌症侵袭性中发挥作用。在癌症进展过程中，肿瘤细胞与相邻的AT形成代谢共生关系。成熟脂肪细胞为癌细胞提供脂肪因子和脂质，而来自AT的基质细胞和免疫细胞浸润癌组织并在肿瘤微环境中局部分泌旁分泌因子。本综述重点关注AT与肿瘤细胞之间的相互作用，这种相互作用促进肿瘤生长并增加细胞脂质代谢、转移和化疗耐药性。
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