膜突蛋白在下唇口腔癌发生中的作用
Moesin Involvement in Oral Carcinogenesis of the Lower Lip.
作者信息
Assao Agnes, Yoshino Paula Midori, Medeiros Maria Carolina Malta, Carvalho André Lopes, Soares Fernando Augusto, Kowalski Luiz Paulo, Oliveira Denise Tostes
机构信息
Department of Surgery, Stomatology, Pathology and Radiology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil.
Fundação Pio XII Institution, Cancer Hospital of Barretos, Barretos, São Paulo, Brazil.
出版信息
Anticancer Res. 2018 May;38(5):2755-2760. doi: 10.21873/anticanres.12518.
BACKGROUND/AIM: This study analyzed moesin immunoexpression in 91 lip squamous cell carcinomas and its influence in patients' prognosis.
MATERIALS AND METHODS
Moesin immunoexpression was evaluated at the invasive tumor front by a semi-quantitative score method. The association of moesin with the clinicopathological variables was analyzed by the Chi-square test, the survival rates were calculated by Kaplan-Meier and the survival curves compared using the log-rank test.
RESULTS
The expression of moesin was strong at the invasive tumor front and weak/negative in differentiated cells such as keratin pearls. There was no association between moesin expression and the clinicopathological variables, but there was a tendency for patients with lip cancer and strong moesin expression to have lower 5- and 10-year overall and disease-free survival rates.
CONCLUSION
Our results confirm the participation of moesin in oral carcinogenesis and suggest that this protein can influence the survival rates of patients with lip squamous cell carcinoma.
背景/目的：本研究分析了91例唇鳞状细胞癌中埃兹蛋白的免疫表达及其对患者预后的影响。
材料与方法
采用半定量评分法评估侵袭性肿瘤前沿的埃兹蛋白免疫表达。通过卡方检验分析埃兹蛋白与临床病理变量的相关性，采用Kaplan-Meier法计算生存率，并使用对数秩检验比较生存曲线。
结果
埃兹蛋白在侵袭性肿瘤前沿表达强烈，在角质珠等分化细胞中表达弱/阴性。埃兹蛋白表达与临床病理变量之间无相关性，但唇癌且埃兹蛋白表达强烈的患者5年和10年总生存率及无病生存率有降低趋势。
结论
我们的结果证实埃兹蛋白参与口腔癌发生，并表明该蛋白可影响唇鳞状细胞癌患者的生存率。
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