[用于治疗心肌梗死的可注射水凝胶的现状与展望]
[Present status and prospects of injectable hydrogels for treatment of myocardial infarction].
作者信息
Wen Ying, Jiang Xuejun
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2017 Feb;34(1):156-60. doi: 10.7507/1001-5515.201508044.
Abstract
Survivors from myocardial infarction(MI) eventually develop heart failure due to the post-infarct ventricular remodeling which could not be suppressed by existing treatments. Currently, coronary heart disease has become the major cause of heart failure instead of rheumatic heart disease in China. For this reason, seeking effective treatment to prevent post-infarct ventricular remodeling is urgent. Intramyocardial injection of hydrogels as a new strategy for MI treatment has made great progress recently. This review discusses the principle, present status,mechanisms and prospects of injectable hydrogel therapies for MI.
摘要
心肌梗死（MI）幸存者最终会因梗死后期心室重构而发展为心力衰竭，现有治疗方法无法抑制这种重构。目前，在中国，冠心病已成为心力衰竭的主要病因，而非风湿性心脏病。因此，寻求有效的治疗方法来预防梗死后期心室重构迫在眉睫。心肌内注射水凝胶作为一种治疗MI的新策略，近年来取得了很大进展。本文综述了可注射水凝胶治疗MI的原理、现状、机制和前景。
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