塔洛明通过 PI3K/Akt 依赖性途径促进星孢菌素分化的 RGC-5 细胞的神经突生长。
Talaumidin Promotes Neurite Outgrowth of Staurosporine-Differentiated RGC-5 Cells Through PI3K/Akt-Dependent Pathways.
机构信息
Graduate School and Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan.
Division of Health Sciences, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.
出版信息
Adv Exp Med Biol. 2018;1074:649-653. doi: 10.1007/978-3-319-75402-4_79.
Talaumidin, a tetrahydrofuran neolignan isolated from the root of Aristolochia arcuata, was an interesting small molecule with neurotrophic activity in the cultured neuron. Talaumidin can promote neurite outgrowth from neurons. However, the mechanism by which talaumidin exerts its neurotrophic actions on retinal neurons has not been elucidated to date. In this study, we describe that talaumidin has neurotrophic properties such as neurite outgrowth in neuroretinal cell line, RGC-5. Talaumidin promotes staurosporine-induced neurite outgrowth in RGC-5 cells. The neurite outgrowth effect of talaumidin was inhibited by phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, but not by Erk inhibitor, PD98059. These data suggest that talaumidin promotes neurite outgrowth through PI3K/Akt pathway and that the potential of talaumidin serves as a promising lead compound for the treatment of retinal degenerative disorders.
塔拉乌敏，一种从马兜铃属弯管马兜铃的根部分离得到的四氢呋喃新木脂素，是一种具有神经营养活性的有趣小分子。塔拉乌敏可以促进神经元的突起生长。然而，塔拉乌敏对视网膜神经元发挥神经营养作用的机制尚未阐明。在这项研究中，我们描述了塔拉乌敏具有神经营养特性，如神经视网膜细胞系 RGC-5 中的突起生长。塔拉乌敏促进了 staurosporine 诱导的 RGC-5 细胞的突起生长。PI3K 抑制剂 LY294002 抑制了塔拉乌敏的突起生长作用，但 Erk 抑制剂 PD98059 没有抑制。这些数据表明，塔拉乌敏通过 PI3K/Akt 通路促进突起生长，塔拉乌敏具有作为治疗视网膜退行性疾病的有前途的先导化合物的潜力。
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