The correlation between striatal and cortical binding ratio of C-PiB-PET in amyloid-uptake-positive patients.

PURPOSE

In subjects with amyloid deposition, striatal accumulation of C-Pittsburgh compound B (PiB) demonstrated by positron emission tomography (PET) is related to the stage of Alzheimer's disease (AD). In this study, we investigated the correlation between striatal and cortical non-displaceable binding potential (BP).

METHODS

Seventy-three subjects who complained of cognitive disturbance underwent dynamic PiB-PET studies and showed positive PiB accumulation were retrospectively selected. These subjects included 34 AD, 26 mild cognitive impairment, 2 frontotemporal lobar degeneration, 2 Parkinson's disease, 5 dementia with Lewy bodies, and 4 undefined diagnosis patients. Individual BP images were produced from the dynamic data of the PiB-PET study, and voxel-based analyses were performed to estimate the correlations between striatal and other regional cortical BP measures.

RESULTS

There were highly significant correlations between striatal and prefrontal BP, with the highest correlation being demonstrated in left Brodmann area 11. We found that almost all of the high cortical BP values correlated with striatal BP values, with the exception of the occipital cortex with low correlation.

CONCLUSION

Our study demonstrated positive correlations in amyloid deposits between the striatum and other cortical areas with functional and anatomical links. The amyloid distribution in the brain is not random, but spreads following the functional and anatomical connections.