冷冻电解治疗心房颤动：一项初步可行性研究。
Cryoelectrolysis for Treatment of Atrial Fibrillation: A First Order Feasibility Study.
作者信息
Hjouj M, Krishnan H, Rubinsky B
机构信息
The Medical Imaging Department, Faculty of Health Professions Al Quds University, Jerusalem, Palestinian Authority.
Department of Mechanical Engineering, University of California Berkeley, Berkeley CA, USA.
出版信息
Cryo Letters. 2017 Nov/Dec;38(6):428-433.
UNLABELLED
BACKGROUND: Catheter based treatment of atrial fibrillation (AFib) involves ablation of groups of cells near the pulmonary vein.
OBJECTIVE
The goal of this study was to evaluate the technological feasability of a new technology for catheter-based ablation for treatment of AFib that combines freezing with electrolysis.
MATERIALS AND METHODS
The study was performed on a pH dye stained gel phantom of the pulmonary vein. Freezing was induced with a cryosurgical probe inserted in the vein and electrolysis was delivered through the probe with a DC power supply.
RESULTS
Visual recording of colorimetric changes in pH demonstrate that electrolytic products can propagate through the frozen tissue phantom. For example, a voltage of 9 V and a current of 40 mA delivered through a -15 degree C cryosurgical probe produced an electrolysis impacted rim of over 7 mm width in 2 min.
CONCLUSION
This early stage experimental work suggests that cryoelectrolysis may have potential for treatment of AFib.
未标注
背景：基于导管的心房颤动（AFib）治疗涉及对肺静脉附近细胞群的消融。
目的
本研究的目的是评估一种将冷冻与电解相结合的基于导管消融治疗AFib的新技术的技术可行性。
材料与方法
该研究在肺静脉的pH染料染色凝胶模型上进行。通过插入静脉的冷冻手术探针诱导冷冻，并通过带有直流电源的探针进行电解。
结果
pH比色变化的视觉记录表明，电解产物可在冷冻组织模型中传播。例如，通过-15℃冷冻手术探针施加9V电压和40mA电流，在2分钟内产生了宽度超过7mm的电解影响边缘。
结论
这项早期实验工作表明，冷冻电解可能具有治疗AFib的潜力。
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