平均血小板体积和中性粒细胞/淋巴细胞比率在预测输卵管异位妊娠单剂量甲氨蝶呤治疗成功率中的作用
Role of mean platelet volume and neutrophil/lymphocyte ratio to predict single-dose methotrexate treatment success in tubal ectopic pregnancy.
作者信息
Cekmez Y, Göçmen A, Sanlιkan F, Türkmen S B
出版信息
Clin Exp Obstet Gynecol. 2016;43(4):509-511.
OBJECTIVE
The aim of the study was to evaluate the value of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) to predict single-dose methotrexate (MTX) treatment success in ectopic pregnancy (EP).
MATERIALS AND METHODS
A total of 115 EP diagnosed and hemodynamically stable women were enrolled in the study and divided into two groups as group 1, the treatment success group (n= 78) and group 2, the treatment failure group (n = 37). The authors compared the groups in terms of MPV and NLR.
RESULTS
MPV and NLR levels were higher in MTX treatment successful group than in failure group.The cut-off values of MPV and NLR were determined as 10.1 fL and 1.82, respectively. These cut off values showed similar sensitivity and specificity in prediction of MTX treat- ment success.
CONCLUSION
MPV and NLR can be used as reliable markers to predict single-dose MTX treatment success however further studies are needed.
目的
本研究旨在评估平均血小板体积（MPV）和中性粒细胞/淋巴细胞比值（NLR）对预测单剂量甲氨蝶呤（MTX）治疗异位妊娠（EP）成功的价值。
材料与方法
本研究共纳入115例经诊断且血流动力学稳定的异位妊娠女性，并将其分为两组，即治疗成功组（n = 78）和治疗失败组（n = 37）。作者比较了两组的MPV和NLR。
结果
MTX治疗成功组的MPV和NLR水平高于失败组。MPV和NLR的截断值分别确定为10.1 fL和1.82。这些截断值在预测MTX治疗成功方面显示出相似的敏感性和特异性。
结论
MPV和NLR可作为预测单剂量MTX治疗成功的可靠标志物，然而仍需要进一步研究。
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